Anti-CAPN1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CAPN1 Antibody (CSB-PA004490ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Calcium-activated neutral proteinase 1 Antibody, CANP 1 Antibody,Calpain mu-type Antibody,Calpain-1 large subunit Antibody,Cell proliferation-inducing gene 30 protein Antibody,Micromolar-calpain Antibody,muCANP Antibody,CAPN1 Antibody,CANPL1 Antibody,PIG30 Antibody

More alternative names for the antibody
Ca2 activated neutral protease antibody|Calcium activated neutral proteinase antibody|Calcium activated neutral proteinase small subunit antibody|Calcium dependent protease small subunit 1 antibody|Calcium dependent protease small subunit antibody|Calcium-activated neutral proteinase 1 antibody|Calpain 1 antibody|Calpain 1 large subunit antibody|Calpain 1, (mu/I) large subunit antibody|Calpain mu type antibody|Calpain mu-type antibody|Calpain regulatory subunit antibody|Calpain small subunit 1 antibody|Calpain, large polypeptide L1 antibody|Calpain-1 catalytic subunit antibody|Calpain-1 large subunit antibody|CAN1_HUMAN antibody|CANP 1 antibody|CANP antibody|CANP small subunit antibody|CANP1 antibody|CANPL 1 antibody|CANPL1 antibody|CAPN 1 antibody|CAPN1 antibody|Cell proliferation inducing protein 30 antibody|Cell proliferation-inducing gene 30 protein antibody|Micromolar Calpain antibody|Micromolar-calpain antibody|Mu Calpain antibody|muCANP antibody|muCL antibody
Anti-Calpain 1 antibody [EPR3319] (ab108400)
Close sc-32796|sc-32327|sc-390677|sc-7530|sc-271313|sc-13990|sc-7531|sc-81171|sc-58326|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CAPN1 Antibody

Catalogue No.

CSB-PA004490ESR1HU

Reactivity

Human

Immunogen

Recombinant human Calpain-1 catalytic subunit protein (20-330AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

81 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:823( Human), Entrez Gene:12333( Mouse), Entrez Gene:29153( Rat), Omim:114220( Human), SwissProt:P07384( Human), SwissProt:O35350( Mouse), SwissProt:P97571( Rat), Unigene:502842( Human), Unigene:6221( Mouse), Unigene:6037( Rat)

Protein function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. .

Protein tissue specificity

Ubiquitous. .

Involvement in disease

Spastic paraplegia 76, autosomal recessive (SPG76) [MIM:616907]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase C2 family.

Protein post-translational modifications

Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms. .

Protein cellular localization

Cytoplasm . Cell membrane . Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719). .

Research area

All research areas>Synthesis and Degradation>Calpain
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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