No products in the cart.
Rabbit Anti-CARD11 Antibody (CSB-PA866306ESR1HU)
Supplier: CUSABIO BIOTECH CO.
CARD-containing MAGUK protein 1 Antibody,Carma 1 Antibody,CARD11 Antibody,CARMA1 AntibodyMore alternative names for the antibody
0610008L17Rik antibody|2410011D02Rik antibody|Bcl10 interacting maguk protein 3 antibody|BIMP 3 antibody|BIMP3 antibody|CAR11_HUMAN antibody|CARD 11 antibody|CARD containing MAGUK protein 3 antibody|Card maguk protein 1 antibody|CARD-containing MAGUK protein 1 antibody|CARD11 antibody|CARD11 protein antibody|Carma 1 antibody|CARMA1 antibody|Caspase recruitment domain containing protein 11 antibody|Caspase recruitment domain family member 11 antibody|Caspase recruitment domain-containing protein 11 antibody|MGC133069 antibody
Anti-CARD11 antibody – C-terminal (ab189167)
Anti-CARD11 antibody – C-terminal (ab189167)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Caspase recruitment domain-containing protein 11 protein (985-1154AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84433" target="_blank">Entrez Gene:84433( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=108723" target="_blank">Entrez Gene:108723( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/607210" target="_blank">Omim:607210( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q9BXL7" target="_blank">SwissProt:Q9BXL7( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q8CIS0" target="_blank">SwissProt:Q8CIS0( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=648101" target="_blank">Unigene:648101( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=46187" target="_blank">Unigene:46187( Mouse)</a>
|Protein function|| |
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
|Protein tissue specificity|| |
Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. .
|Involvement in disease|| |
B-cell expansion with NFKB and T-cell anergy (BENTA) [MIM:616452]: An autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Immunodeficiency 11 (IMD11) [MIM:615206]: An autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein post-translational modifications|| |
Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling. .
|Protein cellular localization|| |
Cytoplasm . Membrane raft . Note=Colocalized with DPP4 in membrane rafts.
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Neurobiology-Antibodies/">Neurobiology Antibodies</a>><a href="https://antibodyplus.com/product-tag/CARD/">CARD</a><br><a href="https://antibodyplus.com/product-tag/Neurobiology-Antibodies/"> (View all antibody categories related to Neurobiology Antibodies)</a>
AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.
CUSABIO BIOTECH CO.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: