Anti-CARD11 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CARD11 Antibody (CSB-PA866306ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CARD-containing MAGUK protein 1 Antibody,Carma 1 Antibody,CARD11 Antibody,CARMA1 Antibody

More alternative names for the antibody
0610008L17Rik antibody|2410011D02Rik antibody|Bcl10 interacting maguk protein 3 antibody|BIMP 3 antibody|BIMP3 antibody|CAR11_HUMAN antibody|CARD 11 antibody|CARD containing MAGUK protein 3 antibody|Card maguk protein 1 antibody|CARD-containing MAGUK protein 1 antibody|CARD11 antibody|CARD11 protein antibody|Carma 1 antibody|CARMA1 antibody|Caspase recruitment domain containing protein 11 antibody|Caspase recruitment domain family member 11 antibody|Caspase recruitment domain-containing protein 11 antibody|MGC133069 antibody
Anti-CARD11 antibody – C-terminal (ab189167)
Close sc-166910|sc-48737|sc-20458|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:500-2000

Recommended protocols: check protocols

Name

Anti-CARD11 Antibody

Catalogue No.

CSB-PA866306ESR1HU

Reactivity

Human

Immunogen

Recombinant human Caspase recruitment domain-containing protein 11 protein (985-1154AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:500-2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

133 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:84433( Human), Entrez Gene:108723( Mouse), Omim:607210( Human), SwissProt:Q9BXL7( Human), SwissProt:Q8CIS0( Mouse), Unigene:648101( Human), Unigene:46187( Mouse)

Protein function

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

Protein tissue specificity

Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt’s lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. .

Involvement in disease

B-cell expansion with NFKB and T-cell anergy (BENTA) [MIM:616452]: An autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Immunodeficiency 11 (IMD11) [MIM:615206]: An autosomal recessive primary immunodeficiency characterized by normal numbers of T and B-lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B-cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T-cells and defects in T-cell function. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein post-translational modifications

Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling. .

Protein cellular localization

Cytoplasm . Membrane raft . Note=Colocalized with DPP4 in membrane rafts.

Research area

All research areas>Neurobiology Antibodies>CARD
(View all antibody categories related to Neurobiology Antibodies)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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