Anti-CASP14 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CASP14 Antibody (CSB-PA004546ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CASP-14 Antibody,CASP14 Antibody

More alternative names for the antibody
Caspase 14 precursor antibody|Caspase-14 subunit p10 antibody|Caspase14 antibody|CASPE_HUMAN antibody|MGC119078 antibody|MGC119079 antibody|MICE antibody|Mini ICE antibody
Anti-Caspase-14 antibody [EPR12927] (ab174847)
Close sc-136351|sc-56040|sc-48395|sc-48336|sc-5628|sc-515259|sc-9644|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CASP14 Antibody

Catalogue No.

CSB-PA004546ESR1HU

Reactivity

Human

Immunogen

Recombinant human Caspase-14 protein (1-242AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

27 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:23581( Human), Entrez Gene:12365( Mouse), Entrez Gene:299587( Rat), Omim:605848( Human), SwissProt:P31944( Human), SwissProt:O89094( Mouse), Unigene:466057( Human), Unigene:20940( Mouse), Unigene:228179( Rat)

Protein function

Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). .

Protein tissue specificity

Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846). .

Protein sequence and domain

Belongs to the peptidase C14A family.

Protein post-translational modifications

Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form (PubMed:22825846). Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme (PubMed:12200134). .

Protein cellular localization

Cytoplasm . Nucleus .

Research area

All research areas>Tumor Suppressor/Apoptosis>Caspase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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