Anti-CBFA2T2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CBFA2T2 Antibody (CSB-PA004575ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Protein CBFA2T2 Antibody,ETO homologous on chromosome 20 Antibody,MTG8-like protein Antibody,MTG8-related protein 1 Antibody,Myeloid translocation-related protein 1 Antibody,p85 Antibody,CBFA2T2 Antibody,EHT Antibody,MTGR1 Antibody

More alternative names for the antibody
AML1 MTG8 antibody|p85 antibody|Protein CBFA2T2 antibody|ZMYND 3 antibody|ZMYND3 antibody
Anti-MTGR1 antibody (ab96161)
Close sc-390114|sc-81326|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CBFA2T2 Antibody

Catalogue No.

CSB-PA004575ESR1HU

Reactivity

Human

Immunogen

Recombinant human Protein CBFA2T2 protein (325-604AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

67 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9139( Human), Entrez Gene:12396( Mouse), Entrez Gene:296293( Rat), Omim:601308( Human), Omim:603672( Human), SwissProt:O43439( Human), SwissProt:O70374( Mouse), Unigene:153934( Human), Unigene:29914( Mouse), Unigene:58348( Rat)

Protein function

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). .

Protein tissue specificity

Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus. .

Involvement in disease

Note=A chromosomal aberration involving CBFA2T2 is found in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Translocation t(9;20)(p13;q11) with PAX5. .; Note=A chromosomal aberration involving CBFA2T2 is found in acute myeloid leukemia. Translocation t(20;21)(q11;q22) with RUNX1/AML1. .

Protein sequence and domain

Belongs to the CBFA2T family. Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>MTGR
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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