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Rabbit Anti-CBFA2T2 Antibody (CSB-PA004575ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Protein CBFA2T2 Antibody,ETO homologous on chromosome 20 Antibody,MTG8-like protein Antibody,MTG8-related protein 1 Antibody,Myeloid translocation-related protein 1 Antibody,p85 Antibody,CBFA2T2 Antibody,EHT Antibody,MTGR1 AntibodyMore alternative names for the antibody
AML1 MTG8 antibody|p85 antibody|Protein CBFA2T2 antibody|ZMYND 3 antibody|ZMYND3 antibody
Anti-MTGR1 antibody (ab96161)
Anti-MTGR1 antibody (ab96161)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Protein CBFA2T2 protein (325-604AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:9139( Human), Entrez Gene:12396( Mouse), Entrez Gene:296293( Rat), Omim:601308( Human), Omim:603672( Human), SwissProt:O43439( Human), SwissProt:O70374( Mouse), Unigene:153934( Human), Unigene:29914( Mouse), Unigene:58348( Rat)
|Protein function|| |
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). .
|Protein tissue specificity|| |
Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus. .
|Involvement in disease|| |
Note=A chromosomal aberration involving CBFA2T2 is found in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Translocation t(9;20)(p13;q11) with PAX5. .; Note=A chromosomal aberration involving CBFA2T2 is found in acute myeloid leukemia. Translocation t(20;21)(q11;q22) with RUNX1/AML1. .
|Protein sequence and domain|| |
Belongs to the CBFA2T family. Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.
|Protein cellular localization|| |
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|Product type|| |
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