Anti-CCAR1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CCAR1 Antibody (CSB-PA816898ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Cell cycle and apoptosis regulatory protein 1 Antibody,CARP-1 Antibody,Death inducer with SAP domain Antibody,CCAR1 Antibody,CARP1 Antibody, DIS Antibody

More alternative names for the antibody
CARP-1 antibody|Carp1 antibody|Ccar1 antibody|CCAR1_HUMAN antibody|Cell cycle and apoptosis regulatory protein 1 antibody|cell division cycle and apoptosis regulator 1 antibody|Cell division cycle and apoptosis regulator protein 1 antibody|Death inducer with SAP domain antibody|FLJ10590 antibody|FLJ10839 antibody|FLJ13376 antibody|FLJ20734 antibody|MGC7730 antibody|RP11-437A18.1 antibody
Anti-DIS antibody (ab70243)
Close sc-69263|

Recommended applications: ELISA, WB

Recommended dilution: Recommended dilution:WB:1:500-2000

Recommended protocols: check protocols

Name

Anti-CCAR1 Antibody

Catalogue No.

CSB-PA816898ESR2HU

Reactivity

Human

Immunogen

Recombinant human Cell division cycle and apoptosis regulator protein 1 protein (1-200AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

Recommended dilution:WB:1:500-2000

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

132 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:423692( Chicken), Entrez Gene:450498( Chimpanzee), Entrez Gene:767587( Cow), Entrez Gene:479230( Dog), Entrez Gene:55749( Human), Entrez Gene:67500( Mouse), Entrez Gene:361849( Rat), Omim:612569( Human), SwissProt:Q8IX12( Human), SwissProt:Q8CH18( Mouse), Unigene:49853( Human), Unigene:196371( Mouse)

Protein function

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). .

Protein tissue specificity

Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. .

Protein cellular localization

Cytoplasm, perinuclear region .

Research area

All research areas>Transcription Regulators>CARP
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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