Anti-CCND3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CCND3 Antibody (CSB-PA004814ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CCND3 Antibody

More alternative names for the antibody
CCND 3 antibody|Ccnd3 antibody|CCND3_HUMAN antibody|CyclinD3 antibody|D3 type cyclin antibody|G1 S specific cyclin D3 antibody|G1/S specific cyclin D3 antibody|G1/S-specific cyclin-D3 antibody
Anti-Cyclin D3 antibody [DCS2.2] (ab28283)
Close sc-135875|sc-453|sc-182|sc-6283|sc-56307|sc-56308|sc-755|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CCND3 Antibody

Catalogue No.

CSB-PA004814ESR2HU

Reactivity

Human

Immunogen

Recombinant human G1/S-specific cyclin-D3 protein (1-292AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

32 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:896( Human), Entrez Gene:12445( Mouse), Entrez Gene:25193( Rat), Omim:123834( Human), SwissProt:P30281( Human), SwissProt:P30282( Mouse), SwissProt:P48961( Rat), Unigene:534307( Human), Unigene:27291( Mouse), Unigene:472101( Mouse), Unigene:3483( Rat), Unigene:54319( Rat)

Protein function

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. .

Protein sequence and domain

Belongs to the cyclin family. Cyclin D subfamily.

Protein post-translational modifications

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. .

Protein cellular localization

Nucleus . Cytoplasm . Membrane . Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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