Anti-CCP110 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CCP110 Antibody (CSB-PA528588ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Centriolar coiled-coil protein of 110 kDa Antibody,Centrosomal protein of 110 kDa Antibody,CP110 Antibody,Cep110 Antibody,CCP110 Antibody,CEP110 Antibody,CP110 Antibody,KIAA0419 Antibody

More alternative names for the antibody
110 kDa centrosomal protein antibody|CCP110 antibody|Centriolar coiled coil protein 110kDa antibody|Centrosomal protein 110 kDa antibody|Centrosomal protein CP110 antibody|Centrosomal protein of 110 kDa antibody|Cep110 antibody|CP110 antibody|CP110_HUMAN antibody|DKFZp781G1416 antibody|FAN antibody|KIAA0419 antibody
Anti-CP110 antibody – C-terminal (ab189885)
Close sc-136629|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CCP110 Antibody

Catalogue No.

CSB-PA528588ESR1HU

Reactivity

Human

Immunogen

Recombinant human Centriolar coiled-coil protein of 110 kDa protein (1-280AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

113 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:9738( Human), Entrez Gene:361634( Rat), Omim:609544( Human), SwissProt:O43303( Human), Unigene:279912( Human), Unigene:19479( Rat)

Protein function

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). .

Protein tissue specificity

Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. .

Protein post-translational modifications

Phosphorylated by CDKs. .; Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. .

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact. .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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