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Rabbit Anti-CD244 Antibody (CSB-PA861192ESR1HU)
Supplier: CUSABIO BIOTECH CO.
NK cell activation-inducing ligand Antibody,NAIL Antibody,NK cell type I receptor protein 2B4 Antibody,NKR2B4 Antibody,h2B4 Antibody,SLAM family member 4 Antibody,SLAMF4 Antibody,Signaling lymphocytic activation molecule 4 Antibody,CD244 Antibody,2B4 AntibodyMore alternative names for the antibody
2B4 antibody|C9.1 antibody|CD244 antibody|CD244 antigen antibody|CD244 molecule antibody|CD244 molecule natural killer cell receptor 2B4 antibody|CD244 natural killer cell receptor 2B4 antibody|CD244_HUMAN antibody|F730046O15Rik antibody|h2B4 antibody|Ly90 antibody|NAIL antibody|Natural killer cell activation-inducing ligand antibody|Natural killer cell receptor 2B4 antibody|NK cell activation inducing ligand antibody|NK cell activation inducing ligand NAIL antibody|NK cell activation-inducing ligand antibody|NK cell type I receptor protein 2B4 antibody|NKR2B4 antibody|Nmrk antibody|Non-MHC restricted killing associated antibody|OTTHUMP00000027884 antibody|p38 antibody|signaling lymphocytic activation molecule 4 antibody|SLAM family, member 4 antibody|SLAMF4 antibody
Anti-CD244 antibody (ab113289)
Anti-CD244 antibody (ab113289)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Natural killer cell receptor 2B4 protein (22-224AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:51744( Human), Entrez Gene:18106( Mouse), Entrez Gene:64025( Rat), Omim:605554( Human), SwissProt:Q9BZW8( Human), SwissProt:Q07763( Mouse), SwissProt:Q9JLM2( Rat), Unigene:157872( Human), Unigene:2299( Mouse), Unigene:113760( Rat), Unigene:53994( Rat)
|Protein function|| |
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). .
|Protein tissue specificity|| |
Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed in all natural killer (NK) cells, monocytes and basophils, TCR-gamma/delta+ T-cells, monocytes, basophils, and on a subset of CD8(+) T-cells. .
|Protein sequence and domain|| |
The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A ‘three-pronged’ mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
|Protein post-translational modifications|| |
N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding. .; Phosphorylated by FYN and CSK on tyrosine residues following activation. Coligation with inhibitory receptors such as KIR2DL1 inhibits phosphorylation upon contact of NK cells with sensitive target cells. .
|Protein cellular localization|| |
Membrane ; Single-pass type I membrane protein . Cell membrane . Note=Receptor engagement results in a recruitment to lipid drafts essential for the subsequent tyrosine phosphorylation of the ITSMs. .
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CUSABIO BIOTECH CO.
|Product type|| |
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