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Rabbit Anti-CD5L Antibody (CSB-PA004948ESR1HU)
Supplier: CUSABIO BIOTECH CO.
CT-2 Antibody,IgM-associated peptide Antibody,SP-alpha Antibody,CD5L Antibody,API6 AntibodyMore alternative names for the antibody
AAC-11 antibody|AI047839 antibody|API6 antibody|apoptosis inhibitor 6 antibody|Apoptosis inhibitor expressed by macrophages antibody|apoptosis inhibitor of macrophages antibody|Apoptosis inhibitory 6 antibody|CD5 antigen-like antibody|CD5L antibody|CD5L_HUMAN antibody|CT 2 antibody|CT-2 antibody|IgM associated peptide antibody|IgM-associated peptide antibody|LYMPHOCYTE ANTIGEN CD5 LIKE antibody|Pdp 1/6 antibody|PRO229 antibody|SCAVENGER RECEPTOR CYSTEINE RICH FAMILY antibody|SP alpha antibody|SP-alpha antibody|Spalpha antibody
Anti-CD5L antibody (ab45408)
Anti-CD5L antibody (ab45408)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:200-1000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human CD5 antigen-like protein (20-347AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983). .
|Protein tissue specificity|| |
Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues. .
|Protein post-translational modifications|| |
Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605). .
|Protein cellular localization|| |
Secreted . Cytoplasm . Note=Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity). .
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CUSABIO BIOTECH CO.
|Product type|| |
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