Anti-CDCA8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CDCA8 Antibody (CSB-PA700653ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Cell division cycle-associated protein 8 Antibody,Dasra-B Antibody,hDasra-B Antibody,Pluripotent embryonic stem cell-related gene 3 protein Antibody,CDCA8 Antibody,PESCRG3 Antibody

More alternative names for the antibody
BOR antibody|
Anti-Borealin/CDCA8 antibody (ab70910)
Close sc-376635|sc-130705|sc-98869|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CDCA8 Antibody

Catalogue No.

CSB-PA700653ESR2HU

Reactivity

Human

Immunogen

Recombinant human Borealin protein (1-280AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

31 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:55143( Human), Omim:609977( Human), SwissProt:Q53HL2( Human), Unigene:524571( Human)

Protein function

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. .

Protein sequence and domain

Belongs to the borealin family. The C-terminal region (aa 207-280) represents the dimerization motif.

Protein post-translational modifications

Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA. .; Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3. .

Protein cellular localization

Nucleus, nucleolus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere . Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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