Anti-CDK8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CDK8 Antibody (CSB-PA005077DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Cell division protein kinase 8 Antibody,Mediator complex subunit CDK8 Antibody,Mediator of RNA polymerase II transcription subunit CDK8 Antibody,Protein kinase K35 Antibody

More alternative names for the antibody
cdk8 antibody|CDK8 protein kinase antibody|CDK8_HUMAN antibody|Cell Division Kinase 8 antibody|Cell division protein kinase 8 antibody|Cyclin Dependent kinase 8 antibody|Cyclin-dependent kinase 8 antibody|K35 antibody|Mediator complex subunit cdk8 antibody|Mediator of RNA polymerase II transcription subunit cdk8 antibody|Protein kinase K35 antibody
Anti-Cdk8 antibody [EPR3699(N)] – N-terminal (ab176559)
Close sc-1521|sc-13155|sc-5612|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CDK8 Antibody

Catalogue No.

CSB-PA005077DSR2HU

Reactivity

Human

Immunogen

Recombinant human Cyclin-dependent kinase 8 protein (365-464AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

53 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1024( Human), Entrez Gene:264064( Mouse), Omim:603184( Human), SwissProt:P49336( Human), SwissProt:Q8R3L8( Mouse), Unigene:382306( Human), Unigene:260576( Mouse)

Protein function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. .

Protein sequence and domain

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Protein cellular localization

Nucleus .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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