Anti-CETN2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CETN2 Antibody (CSB-PA005265DSR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Caltractin isoform 1 Antibody,CETN2 Antibody,CALT Antibody,CEN2 Antibody

More alternative names for the antibody
20kD calcium binding protein antibody|CALT antibody|caltractin antibody|Caltractin isoform 1 antibody|CEN2 antibody|centrin antibody|centrin, EF hand protein, 2 antibody|Centrin-2 antibody|Centrin2 antibody|CETN2 antibody|CETN2_HUMAN antibody|EF hand protein 2 antibody|EF-hand protein antibody
Anti-Centrin 2 antibody (ab196554)
Close sc-50452|sc-293192|sc-27793|sc-27794|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CETN2 Antibody

Catalogue No.

CSB-PA005265DSR1HU

Reactivity

Human

Immunogen

Recombinant human Centrin-2 protein (1-172AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

19 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1069( Human), Entrez Gene:26370( Mouse), Entrez Gene:84593( Rat), Omim:300006( Human), SwissProt:P41208( Human), SwissProt:Q9R1K9( Mouse), Unigene:82794( Human), Unigene:24643( Mouse), Unigene:9472( Rat)

Protein function

Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.; Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.; The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5′-to-3′ direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.; Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388). .

Protein sequence and domain

Belongs to the centrin family.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus . Note=Centrosome of S-phase, interphase and mitotic cells.

Research area

All research areas>Structural Proteins>Centrin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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