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Rabbit Anti-CHMP2B Antibody (CSB-PA891990ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Charged multivesicular body protein 2b Antibody,CHMP2.5 Antibody,Chromatin-modifying protein 2b Antibody,CHMP2b Antibody,Vacuolar protein sorting-associated protein 2-2 Antibody,Vps2-2 Antibody,hVps2-2 Antibody,CHMP2B Antibody,CGI-84 AntibodyMore alternative names for the antibody
ALS17 antibody|Charged multivesicular body protein 2b antibody|CHM2B_HUMAN antibody|CHMP family, member 2B antibody|CHMP2.5 antibody|CHMP2b antibody|Chromatin modifying protein 2b antibody|Chromatin-modifying protein 2b antibody|DMT1 antibody|hVps2-2 antibody|Vacuolar protein sorting 2, yeast, homolog of, B antibody|Vacuolar protein sorting 2-2 antibody|Vacuolar protein sorting-associated protein 2-2 antibody|VPS2 homolog B antibody|Vps2-2 antibody|VPS2B antibody
Anti-CHMP2B antibody (ab33174)
Anti-CHMP2B antibody (ab33174)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Charged multivesicular body protein 2b protein (1-213AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
|Protein tissue specificity|| |
Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen. .
|Involvement in disease|| |
Frontotemporal dementia, chromosome 3-linked (FTD3) [MIM:600795]: Characterized by an onset of dementia in the late 50’s initially characterized by behavioral and personality changes including apathy, restlessness, disinhibition and hyperorality, progressing to stereotyped behaviors, non-fluent aphasia, mutism and dystonia, with a marked lack of insight. The brains of individuals with FTD3 have no distinctive neuropathological features. They show global cortical and central atrophy, but no beta-amyloid deposits. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Amyotrophic lateral sclerosis 17 (ALS17) [MIM:614696]: An adult-onset progressive neurodegenerative disorder with predominantly lower motor neuron involvement, manifest as muscle weakness and wasting of the upper and lower limbs, bulbar signs, and respiratory insufficiency. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the SNF7 family. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity).
|Protein cellular localization|| |
Cytoplasm, cytosol . Late endosome membrane ; Peripheral membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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