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Rabbit Anti-CHMP4B Antibody (CSB-PA887976ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Charged multivesicular body protein 4b Antibody,Chromatin-modifying protein 4b Antibody,CHMP4b Antibody,SNF7 homolog associated with Alix 1 Antibody,SNF7-2 Antibody,hSnf7-2 Antibody,Vacuolar protein sorting-associated protein 32-2 Antibody,Vps32-2 Antibody,hVps32-2 Antibody,CHMP4B Antibody,C20orf178 Antibody,SHAX1 AntibodyMore alternative names for the antibody
Charged multivesicular body protein 4b antibody|CHM4B_HUMAN antibody|chmp4b antibody|Chromatin-modifying protein 4b antibody|hSnf7-2 antibody|hVps32-2 antibody|SNF7 homolog associated with Alix 1 antibody|SNF7-2 antibody|Vacuolar protein sorting-associated protein 32-2 antibody|Vps32-2 antibody
Anti-CHMP4B antibody (ab105767)
Anti-CHMP4B antibody (ab105767)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Charged multivesicular body protein 4b protein (1-224AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:128866( Human), Entrez Gene:75608( Mouse), Entrez Gene:312254( Rat), Entrez Gene:393164( Zebrafish), Omim:610897( Human), SwissProt:Q9H444( Human), SwissProt:Q9D8B3( Mouse), SwissProt:Q7ZVC4( Zebrafish), Unigene:472471( Human), Unigene:262480( Mouse), Unigene:74679( Zebrafish)
|Protein function|| |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). .; (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. .
|Protein tissue specificity|| |
Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes. .
|Involvement in disease|| |
Cataract 31, multiple types (CTRCT31) [MIM:605387]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT31 includes posterior polar, progressive posterior subcapsular, nuclear, and anterior subcapsular cataracts. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the SNF7 family. The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
|Protein post-translational modifications|| |
ISGylated. Isgylation weakens its interaction with VPS4A. .
|Protein cellular localization|| |
Cytoplasm, cytosol . Late endosome membrane ; Peripheral membrane protein . Midbody . Nucleus envelope . Note=Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712). .
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CUSABIO BIOTECH CO.
|Product type|| |
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