Anti-CISH Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CISH Antibody (CSB-PA885721ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

CIS Antibody,CIS-1 Antibody,Protein G18 Antibody,Suppressor of cytokine signaling Antibody,SOCS Antibody,CISH Antibody,G18 Antibody

More alternative names for the antibody
BACTS2 antibody|cis 1 antibody|CIS antibody|CIS-1 antibody|CIS1 antibody|Cish antibody|CISH_HUMAN antibody|Cytokine inducible inhibitor of signaling type 1B antibody|Cytokine inducible SH2 containing protein antibody|Cytokine-inducible SH2-containing protein antibody|G18 antibody|Protein G18 antibody|SOCS antibody|Suppressor of cytokine signaling antibody
Anti-CISH antibody – C-terminal (ab191447)
Close sc-166363|sc-74581|sc-166326|sc-15344|sc-1529|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CISH Antibody

Catalogue No.

CSB-PA885721ESR1HU

Reactivity

Human

Immunogen

Recombinant human Cytokine-inducible SH2-containing protein (1-257AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

28 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:395335( Chicken), Entrez Gene:616753( Cow), Entrez Gene:1154( Human), Entrez Gene:12700( Mouse), Entrez Gene:83681( Rat), Omim:602441( Human), SwissProt:Q9PW70( Chicken), SwissProt:Q2HJ53( Cow), SwissProt:Q9NSE2( Human), SwissProt:Q62225( Mouse), SwissProt:O70512( Rat), Unigene:655334( Human), Unigene:4592( Mouse), Unigene:14523( Rat)

Protein function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). .

Protein tissue specificity

Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. .

Protein post-translational modifications

Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa). .

Research area

All research areas>Signaling Intermediates>CIS
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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