Anti-CLIC1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CLIC1 Antibody (CSB-PA005545ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Chloride channel ABP Antibody,Nuclear chloride ion channel 27 Antibody,NCC27 Antibody,Regulatory nuclear chloride ion channel protein Antibody,hRNCC Antibody,CLIC1 Antibody,G6 Antibody,NCC27 Antibody

More alternative names for the antibody
Chloride channel ABP antibody|Chloride intracellular channel 1 antibody|Chloride intracellular channel protein 1 antibody|CLIC 1 antibody|CLIC1 antibody|CLIC1_HUMAN antibody|G6 antibody|hRNCC antibody|NCC 27 antibody|NCC27 antibody|Nuclear chloride ion channel 27 antibody|Nuclear chloride ion channel protein antibody|p64CLCP antibody|Regulatory nuclear chloride ion channel protein antibody|RNCC protein antibody
Anti-CLIC1 antibody (ab77214)
Close sc-81873|sc-271051|sc-51048|sc-374202|sc-51049|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CLIC1 Antibody

Catalogue No.

CSB-PA005545ESR1HU

Reactivity

Human

Immunogen

Recombinant human Chloride intracellular channel protein 1 protein (42-241AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-5000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

26 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:515646( Cow), Entrez Gene:1192( Human), Entrez Gene:114584( Mouse), Entrez Gene:406864( Rat), Omim:602872( Human), SwissProt:Q5E9B7( Cow), SwissProt:O00299( Human), SwissProt:Q9Z1Q5( Mouse), SwissProt:Q95MF9( Rabbit), SwissProt:Q6MG61( Rat), Unigene:414565( Human), Unigene:29524( Mouse), Unigene:203139( Rat)

Protein function

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. .

Protein tissue specificity

Expression is prominent in heart, placenta, liver, kidney and pancreas. .

Protein sequence and domain

Belongs to the chloride channel CLIC family. Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

Protein post-translational modifications

Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.

Protein cellular localization

Nucleus. Nucleus membrane ; Single-pass membrane protein . Cytoplasm. Cell membrane ; Single-pass membrane protein . Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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