Anti-CLIC4 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CLIC4 Antibody (CSB-PA005549ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Intracellular chloride ion channel protein p64H1 Antibody,CLIC4 Antibody

More alternative names for the antibody
Chloride intracellular channel 4 antibody|Chloride intracellular channel 4 (mitochondrial) antibody|Chloride intracellular channel 4 like antibody|Chloride intracellular channel protein 4 antibody|Clic4 antibody|CLIC4_HUMAN antibody|CLIC4L antibody|DKFZP566G223 antibody|FLJ38640 antibody|H1 antibody|HUH1 antibody|Intracellular chloride ion channel protein p64H1 antibody|MC3S5 antibody|mtCLIC antibody|p64H1 antibody
Anti-CLIC4 antibody [EPR14253] (ab183043)
Close sc-135739|sc-130723|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CLIC4 Antibody

Catalogue No.

CSB-PA005549ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Chloride intracellular channel protein 4 protein (1-253AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

28 kDa

Purification

Antigen Affinity purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:25932( Human), Entrez Gene:29876( Mouse), Entrez Gene:83718( Rat), Omim:606536( Human), SwissProt:Q9Y696( Human), SwissProt:Q9QYB1( Mouse), SwissProt:Q9Z0W7( Rat), Unigene:440544( Human), Unigene:257765( Mouse), Unigene:104756( Rat)

Protein function

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). .

Protein tissue specificity

Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. .

Protein sequence and domain

Belongs to the chloride channel CLIC family. Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane ; Single-pass membrane protein . Nucleus matrix. Cell membrane ; Single-pass membrane protein . Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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