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Rabbit Anti-CNGA3 Antibody (CSB-PA613670DSR1HU)
Supplier: CUSABIO BIOTECH CO.
Cyclic nucleotide-gated cation channel alpha-3 Antibody,Cone photoreceptor cGMP-gated channel subunit alpha Antibody,Cyclic nucleotide-gated channel alpha-3 Antibody,CNG channel alpha-3 Antibody,CNG-3 Antibody,CNG3 Antibody,CNGA3 Antibody,CNCG3 AntibodyMore alternative names for the antibody
ACHM2 antibody|CCNC1 antibody|CCNCa antibody|CCNCalpha antibody|CNCG3 antibody|CNG 3 antibody|CNG channel alpha 3 antibody|CNG channel alpha-3 antibody|CNG-3 antibody|CNG3 antibody|CNGA3 antibody|Cnga3 cyclic nucleotide gated channel alpha 3 antibody|CNGA3_HUMAN antibody|Cone photoreceptor cGMP gated channel antibody|Cone photoreceptor cGMP gated channel alpha subunit antibody|Cone photoreceptor cGMP gated channel subunit alpha antibody|Cone photoreceptor cGMP-gated channel subunit alpha antibody|Cyclic nucleotide gated cation channel alpha 3 antibody|Cyclic nucleotide gated channel alpha 3 antibody|Cyclic nucleotide gated channel olfactory 3 antibody|Cyclic nucleotide gated channel rod photoreceptor subunit alpha antibody|Cyclic nucleotide-gated cation channel alpha-3 antibody|Cyclic nucleotide-gated channel alpha-3 antibody|OTTHUMP00000161120 antibody
Anti-CNG3 antibody (ab97500)
Anti-CNG3 antibody (ab97500)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Cyclic nucleotide-gated cation channel alpha-3 protein (1-165AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. .
|Protein tissue specificity|| |
Prominently expressed in retina.
|Involvement in disease|| |
Achromatopsia 2 (ACHM2) [MIM:216900]: An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily. The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits.
|Protein cellular localization|| |
Membrane; Multi-pass membrane protein.
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CUSABIO BIOTECH CO.
|Product type|| |
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