Anti-COMMD1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-COMMD1 Antibody (CSB-PA818712ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

COMM domain-containing protein 1 Antibody,Protein Murr1 Antibody,COMMD1 Antibody,C2orf5 Antibody,MURR1 Antibody

More alternative names for the antibody
C2orf5 antibody|COMD1 antibody|COMD1_HUMAN antibody|COMM domain-containing protein 1 antibody|COMMD1 antibody|Copper metabolism (Murr1) domain containing 1 antibody|Copper metabolism domain containing 1 antibody|Copper metabolism gene MURR1 antibody|Copper metabolism MURR1 domain-containing protein 1 antibody|MGC27155 antibody|MURR1 antibody|Protein Murr1 antibody
Anti-COMMD1/MURR1 antibody (ab102794)
Close sc-166248|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-COMMD1 Antibody

Catalogue No.

CSB-PA818712ESR2HU

Reactivity

Human

Immunogen

Recombinant human COMM domain-containing protein 1 protein (1-190AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

21 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:150684( Human), Entrez Gene:17846( Mouse), Omim:607238( Human), SwissProt:Q8N668( Human), SwissProt:Q8K4M5( Mouse), Unigene:468702( Human), Unigene:259903( Mouse), Unigene:451238( Mouse)

Protein function

Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141). .

Protein tissue specificity

Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Down-regulated in cancer tissues. .

Protein post-translational modifications

Acetylated by EP300 ina stimuli-specific manner; protecting it from XIAP-mediated proteasomal degradation and required for interaction with RElA in response to stress. .; Ubiquitinated; undergoes both ‘Lys-63’- and ‘Lys-48’-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation. .

Protein cellular localization

Nucleus . Cytoplasm . Endosome membrane . Cytoplasmic vesicle . Early endosome . Recycling endosome . Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.

Research area

All research areas>Signaling Intermediates>COMMD
(View all antibody categories related to Signaling Intermediates)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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