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Rabbit Anti-COMP Antibody (CSB-PA005778ESR1HU)
Supplier: CUSABIO BIOTECH CO.
COMP Antibody,Thrombospondin-5 Antibody,TSP5 Antibody,COMP AntibodyMore alternative names for the antibody
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) antibody|Cartilage oligomeric matrix protein antibody|Cartilage oligomeric matrix protein precursor antibody|COMP antibody|COMP_HUMAN antibody|EDM 1 antibody|EDM1 antibody|EPD 1 antibody|EPD1 antibody|Epiphyseal dysplasia 1 antibody|Epiphyseal dysplasia 1 multiple antibody|Epiphyseal dysplasia multiple 1 antibody|MED antibody|MGC13181 antibody|MGC149768 antibody|PSACH antibody|pseudoachondroplasia (epiphyseal dysplasia 1, multiple) antibody|Pseudoachondroplasia antibody|THBS 5 antibody|THBS5 antibody|Thrombospondin 5 antibody|Thrombospondin-5 antibody|Thrombospondin5 antibody|TSP5 antibody
Anti-COMP antibody [MA37C94 (HC484D1)] (ab11056)
Anti-COMP antibody [MA37C94 (HC484D1)] (ab11056)
Recommended applications: ELISA, WB
Recommended dilution: Recommended dilution:WB:1:500-2000
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Cartilage oligomeric matrix protein (20-160AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). .
|Protein tissue specificity|| |
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. .
|Involvement in disease|| |
Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Pseudoachondroplasia (PSACH) [MIM:177170]: A skeletal dysplasia usually manifesting in the second year of life and characterized by moderate to severe disproportionate short stature, deformity of the lower limbs, brachydactyly, ligamentous laxity, and degenerative joint disease. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the thrombospondin family. The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.; The TSP C-terminal domain mediates interaction with FN1 and ACAN.; Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions.
|Protein cellular localization|| |
Secreted, extracellular space, extracellular matrix.
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|Product type|| |
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