Anti-CRBN Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CRBN Antibody (CSB-PA842761ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Protein cereblon Antibody,CRBN Antibody,AD-006 Antibody

More alternative names for the antibody
2610203G15Rik antibody|2900045O07Rik antibody|AF229032 antibody|AW108261 antibody|Cereblon antibody|Crbn antibody|CRBN_HUMAN antibody|DKFZp781K0715 antibody|MGC27358 antibody|MRT2A antibody|OTTHUMP00000209555 antibody|piL antibody|Protein cereblon antibody|Protein x 0001 antibody
Anti-CRBN antibody (ab98992)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CRBN Antibody

Catalogue No.

CSB-PA842761ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Protein cereblon protein (1-280AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

50 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:51185( Human), Entrez Gene:58799( Mouse), Entrez Gene:297498( Rat), Entrez Gene:445491( Zebrafish), GenBank:NM_016302.2( Human), Omim:607417( Human), SwissProt:Q96SW2( Human), SwissProt:Q8C7D2( Mouse), SwissProt:Q56AP7( Rat), SwissProt:Q68EH9( Zebrafish), Unigene:18925( Human), Unigene:290085( Mouse), Unigene:195259( Rat), Unigene:84847( Zebrafish)

Protein function

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. .

Protein tissue specificity

Widely expressed. Highly expressed in brain. .

Involvement in disease

Mental retardation, autosomal recessive 2A (MRT2A) [MIM:607417]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the CRBN family. The CULT domain binds thalidomide and related drugs, such as pomalidomide and lenalidomide. Drug binding leads to a change in substrate specificity of the human DCX (DDB1-CUL4-X-box) E3 protein ligase complex, while no such change is observed in rodents.

Protein post-translational modifications

Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex. .

Protein cellular localization

Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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