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Rabbit Anti-CRBN Antibody (CSB-PA842761ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Protein cereblon Antibody,CRBN Antibody,AD-006 AntibodyMore alternative names for the antibody
2610203G15Rik antibody|2900045O07Rik antibody|AF229032 antibody|AW108261 antibody|Cereblon antibody|Crbn antibody|CRBN_HUMAN antibody|DKFZp781K0715 antibody|MGC27358 antibody|MRT2A antibody|OTTHUMP00000209555 antibody|piL antibody|Protein cereblon antibody|Protein x 0001 antibody
Anti-CRBN antibody (ab98992)
Anti-CRBN antibody (ab98992)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Protein cereblon protein (1-280AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:51185( Human), Entrez Gene:58799( Mouse), Entrez Gene:297498( Rat), Entrez Gene:445491( Zebrafish), GenBank:NM_016302.2( Human), Omim:607417( Human), SwissProt:Q96SW2( Human), SwissProt:Q8C7D2( Mouse), SwissProt:Q56AP7( Rat), SwissProt:Q68EH9( Zebrafish), Unigene:18925( Human), Unigene:290085( Mouse), Unigene:195259( Rat), Unigene:84847( Zebrafish)
|Protein function|| |
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3. .
|Protein tissue specificity|| |
Widely expressed. Highly expressed in brain. .
|Involvement in disease|| |
Mental retardation, autosomal recessive 2A (MRT2A) [MIM:607417]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the CRBN family. The CULT domain binds thalidomide and related drugs, such as pomalidomide and lenalidomide. Drug binding leads to a change in substrate specificity of the human DCX (DDB1-CUL4-X-box) E3 protein ligase complex, while no such change is observed in rodents.
|Protein post-translational modifications|| |
Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex. .
|Protein cellular localization|| |
Cytoplasm . Nucleus . Membrane ; Peripheral membrane protein .
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CUSABIO BIOTECH CO.
|Product type|| |
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