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Rabbit Anti-CREB3 Antibody (CSB-PA005948ESR1HU)
Supplier: CUSABIO BIOTECH CO.
CREB-3 Antibody,cAMP-responsive element-binding protein 3 Antibody,Leucine zipper protein Antibody,Luman Antibody,Transcription factor LZIP-alpha Antibody,N-terminal Luman Antibody,Transcriptionally active form Antibody,CREB3 Antibody,LZIP AntibodyMore alternative names for the antibody
Basic leucine zipper protein antibody|cAMP responsive element binding protein 3 antibody|Clic AMP responsive element binding protein 3 antibody|CREB 3 antibody|cyclic AMP response element (CRE) binding protein/activating transcription factor 1 antibody|Cyclic AMP responsive element binding protein 3 antibody|Leucine zipper protein antibody|LUMAN antibody|LZIP antibody|MGC15333 antibody|MGC19782 antibody|Transcription factor LZIP alpha antibody
Anti-CREB3 antibody [EPR14215(B)] (ab180119)
Anti-CREB3 antibody [EPR14215(B)] (ab180119)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-1000,IHC:1:20-200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Cyclic AMP-responsive element-binding protein 3 protein (1-230AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.; Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. It’s transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5′-GTGACGT[AG][AG]-3′) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5′-CCAC[GA]-3’half of ERSE II (5′-ATTGG-N-CCACG-3′). Associates with chromatin to the HERPUD1 promoter.
|Protein tissue specificity|| |
Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous. .
|Protein sequence and domain|| |
Belongs to the bZIP family. ATF subfamily.
|Protein post-translational modifications|| |
The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by TM7SF4.; The processed cyclic AMP-responsive element-binding protein 3 is rapidly degraded.; N-glycosylated. .
|Protein cellular localization|| |
Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestred into the cytoplasm by the HCV core protein. .; Isoform 3: Nucleus. Cytoplasm. Note=Predominantly in the nucleus.; Processed cyclic AMP-responsive element-binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).
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CUSABIO BIOTECH CO.
|Product type|| |
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