Anti-CRYBB1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CRYBB1 Antibody (CSB-PA006012ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Beta-crystallin B1 Antibody,Beta-B1 crystallin Antibody,CRYBB1 Antibody

More alternative names for the antibody
Beta crystallin B1 antibody|Beta-B1 crystallin antibody|Beta-crystallin B1 antibody|CATCN3 antibody|CRBB1_HUMAN antibody|CRYBB 1 antibody|Crybb1 antibody|Crystallin beta B1 antibody|CTRCT17 antibody|Eye lens structural protein antibody|OTTHUMP00000028719 antibody
Anti-beta B1 Crystallin antibody (ab54655)
Close sc-374496|sc-48335|sc-376006|

Recommended applications: ELISA, WB

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CRYBB1 Antibody

Catalogue No.

CSB-PA006012ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Beta-crystallin B1 protein (1-252AA)

Host

Rabbit

Applications

ELISA, WB

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

28 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1414( Human), Omim:600929( Human), SwissProt:P53674( Human), Unigene:37135( Human)

Protein function

Crystallins are the dominant structural components of the vertebrate eye lens.

Involvement in disease

Cataract 17, multiple types (CTRCT17) [MIM:611544]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT17 includes nuclear and pulverulent cataracts, among others. Nuclear cataracts affect the central nucleus of the eye, are often not highly visually significant. The density of the opacities varies greatly from fine dots to a dense, white and chalk-like, central cataract. The condition is usually bilateral. Nuclear cataracts are often combined with opacified cortical fibers encircling the nuclear opacity, which are referred to as cortical riders. Pulverulent cataracts are characterized by a dust-like, ‘pulverised’ appearance of the opacities which can be found in any part of the lens. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=CRYBB1 mutations may be a cause of congenital cataract and microcornea syndrome, a disease characterized by the association of congenital cataract and microcornea without any other systemic anomaly or dysmorphism. Clinical findings include a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye, and an inherited cataract, which is most often bilateral posterior polar with opacification in the lens periphery. The cataract progresses to form a total cataract after visual maturity has been achieved, requiring cataract extraction in the first to third decade of life (PubMed:16110300 and PubMed:21972112). .

Protein sequence and domain

Belongs to the beta/gamma-crystallin family. Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Protein post-translational modifications

Specific cleavages in the N-terminal arm occur during lens maturation and give rise to truncated forms, leading to impaired oligomerization and protein insolubilization.

Research area

All research areas>Signaling Intermediates>Crystallin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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