Anti-CSPG4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CSPG4 Antibody (CSB-PA006076ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Chondroitin sulfate proteoglycan 4 Antibody,Chondroitin sulfate proteoglycan NG2 Antibody,Melanoma chondroitin sulfate proteoglycan Antibody,Melanoma-associated chondroitin sulfate proteoglycan Antibody,CSPG4 Antibody,MCSP Antibody

More alternative names for the antibody
4732461B14Rik antibody|AN2 antibody|AN2 proteoglycan antibody|Chondroitin sulfate proteoglycan 4 (melanoma-associated) antibody|Chondroitin sulfate proteoglycan 4 antibody|Chondroitin sulfate proteoglycan NG2 antibody|Cspg4 antibody|Cspg4 chondroitin sulfate proteoglycan 4 antibody|CSPG4_HUMAN antibody|HMW-MAA antibody|HSN tumor-specific antigen antibody|Kiaa4232 antibody|MCSP antibody|MCSPG antibody|MEL-CSPG antibody|Melanoma chondroitin sulfate proteoglycan antibody|Melanoma-associated chondroitin sulfate proteoglycan antibody|MELCSPG antibody|MSK16 antibody|NG2 antibody
Anti-NG2 antibody [HMB45] (ab83508)
Close sc-53508|sc-80003|sc-30922|sc-166179|sc-30923|sc-166251|sc-20162|sc-30921|sc-53389|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CSPG4 Antibody

Catalogue No.

CSB-PA006076ESR1HU

Reactivity

Human

Immunogen

Recombinant human Chondroitin sulfate proteoglycan 4 protein (1950-2210AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

250 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1464( Human), Entrez Gene:121021( Mouse), Omim:601172( Human), SwissProt:Q6UVK1( Human), SwissProt:Q8VHY0( Mouse), Unigene:513044( Human), Unigene:41329( Mouse)

Protein function

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. .

Protein tissue specificity

Detected only in malignant melanoma cells. .

Protein post-translational modifications

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4. .; Phosphorylation by PRKCA regulates its subcellular location and function in cell motility. .

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein ; Extracellular side . Apical cell membrane ; Single-pass type I membrane protein ; Extracellular side . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein ; Extracellular side . Cell surface . Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). .

Research area

All research areas>Signaling Intermediates>NG2
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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