Anti-CSRP3 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CSRP3 Antibody (CSB-PA006087ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Cysteine and glycine-rich protein 3 Antibody,Cardiac LIM protein Antibody,Cysteine-rich protein 3 Antibody,CRP3 Antibody,LIM domain protein Antibody,cardiac Antibody,Muscle LIM protein Antibody,CSRP3 Antibody,CLP Antibody,MLP Antibody

More alternative names for the antibody
cardiac antibody|Cardiac LIM protein antibody|CLP antibody|CMD1M antibody|CMH12 antibody|CRP3 antibody|Csrp3 antibody|CSRP3_HUMAN antibody|Cysteine and glycine-rich protein 3 antibody|Cysteine rich protein 3 antibody|Cysteine-rich protein 3 antibody|LIM domain only 4 antibody|LIM domain protein antibody|LMO4 antibody|MLP antibody|Muscle LIM protein antibody
Anti-CSRP3 antibody [EPR12615(B)] (ab172952)
Close sc-166930|sc-393599|sc-30274|sc-98827|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-CSRP3 Antibody

Catalogue No.

CSB-PA006087ESR2HU

Reactivity

Human, Mouse

Immunogen

Recombinant human Cysteine and glycine-rich protein 3 protein (1-194AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

20 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:540407( Cow), Entrez Gene:8048( Human), Entrez Gene:13009( Mouse), Entrez Gene:117505( Rat), Omim:600824( Human), SwissProt:Q4U0T9( Cow), SwissProt:P50461( Human), SwissProt:P50462( Mouse), SwissProt:P50463( Rat), Unigene:83577( Human), Unigene:17235( Mouse), Unigene:11345( Rat)

Protein function

Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). .; Isoform 2: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. .

Protein tissue specificity

Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983). .

Involvement in disease

Cardiomyopathy, dilated 1M (CMD1M) [MIM:607482]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, familial hypertrophic 12 (CMH12) [MIM:612124]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

LIM zinc-binding domain 1 is required for self-association. LIM zinc-binding domain 1 and LIM zinc-binding domain 2 both are required for optimal actin-bundling activity (PubMed:24934443). LIM zinc-binding domain 1 mediates binding to MYOD1. LIM zinc-binding domain 2 mediates binding to SPTB (By similarity).

Protein post-translational modifications

Phosphorylated by PKC/PRKCA. .

Protein cellular localization

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cytoplasm, myofibril, sarcomere . Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). .; Isoform 2: Cytoplasm, myofibril, sarcomere, Z line .

Research area

All research areas>Transcription Regulators>Cysteine and Glycine-Rich
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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