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Rabbit Anti-CSRP3 Antibody (CSB-PA006087ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Cysteine and glycine-rich protein 3 Antibody,Cardiac LIM protein Antibody,Cysteine-rich protein 3 Antibody,CRP3 Antibody,LIM domain protein Antibody,cardiac Antibody,Muscle LIM protein Antibody,CSRP3 Antibody,CLP Antibody,MLP AntibodyMore alternative names for the antibody
cardiac antibody|Cardiac LIM protein antibody|CLP antibody|CMD1M antibody|CMH12 antibody|CRP3 antibody|Csrp3 antibody|CSRP3_HUMAN antibody|Cysteine and glycine-rich protein 3 antibody|Cysteine rich protein 3 antibody|Cysteine-rich protein 3 antibody|LIM domain only 4 antibody|LIM domain protein antibody|LMO4 antibody|MLP antibody|Muscle LIM protein antibody
Anti-CSRP3 antibody [EPR12615(B)] (ab172952)
Anti-CSRP3 antibody [EPR12615(B)] (ab172952)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Cysteine and glycine-rich protein 3 protein (1-194AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:540407( Cow), Entrez Gene:8048( Human), Entrez Gene:13009( Mouse), Entrez Gene:117505( Rat), Omim:600824( Human), SwissProt:Q4U0T9( Cow), SwissProt:P50461( Human), SwissProt:P50462( Mouse), SwissProt:P50463( Rat), Unigene:83577( Human), Unigene:17235( Mouse), Unigene:11345( Rat)
|Protein function|| |
Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). .; Isoform 2: May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization. .
|Protein tissue specificity|| |
Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983). .
|Involvement in disease|| |
Cardiomyopathy, dilated 1M (CMD1M) [MIM:607482]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Cardiomyopathy, familial hypertrophic 12 (CMH12) [MIM:612124]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
LIM zinc-binding domain 1 is required for self-association. LIM zinc-binding domain 1 and LIM zinc-binding domain 2 both are required for optimal actin-bundling activity (PubMed:24934443). LIM zinc-binding domain 1 mediates binding to MYOD1. LIM zinc-binding domain 2 mediates binding to SPTB (By similarity).
|Protein post-translational modifications|| |
Phosphorylated by PKC/PRKCA. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cytoplasm, myofibril, sarcomere . Note=Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). .; Isoform 2: Cytoplasm, myofibril, sarcomere, Z line .
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|Product type|| |
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