Anti-CYP4V2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-CYP4V2 Antibody (CSB-PA765094ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Cytochrome P450 4V2 Antibody,Docosahexaenoic acid omega-hydroxylase CYP4V2Curated Antibody,CYP4V2 Antibody

More alternative names for the antibody
BCD antibody|CP4V2_HUMAN antibody|CYP4AH1 antibody|CYP4V 2 antibody|CYP4V2 antibody|Cytochrome P450 4V2 antibody|Cytochrome P450, family 4, subfamily V, polypeptide 2 antibody|Retina CYP4V2 antibody
Anti-CYP4V2 antibody (ab90271)
Close sc-104182|sc-101386|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-CYP4V2 Antibody

Catalogue No.

CSB-PA765094ESR1HU

Reactivity

Human

Immunogen

Recombinant human Cytochrome P450 4V2 protein (246-525AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

60 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:285440( Human), Entrez Gene:102294( Mouse), Entrez Gene:266761( Rat), Omim:608614( Human), SwissProt:Q6ZWL3( Human), SwissProt:Q9DBW0( Mouse), SwissProt:A2RRT9( Rat), Unigene:587231( Human), Unigene:245297( Mouse), Unigene:201722( Rat)

Protein function

Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592). .

Protein tissue specificity

Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes. .

Involvement in disease

Bietti crystalline corneoretinal dystrophy (BCD) [MIM:210370]: An autosomal recessive ocular disease characterized by retinal degeneration and marginal corneal dystrophy. Typical features include multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most patients have similar crystals at the corneoscleral limbus. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, they develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the cytochrome P450 family.

Protein cellular localization

Endoplasmic reticulum membrane ; Single-pass membrane protein .

Research area

All research areas>Synthesis and Degradation>CYP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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