Anti-DCP2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DCP2 Antibody (CSB-PA810265ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Nucleoside diphosphate-linked moiety X motif 20 Antibody,Nudix motif 20 Antibody,mRNA-decapping enzyme 2 Antibody,hDpc Antibody,DCP2 Antibody,NUDT20 Antibody

More alternative names for the antibody
DCP2 antibody|DCP2 decapping enzyme homolog (S. cerevisiae) antibody|DCP2, S. cerevisiae, homolog of antibody|DCP2_HUMAN antibody|decapping enzyme 2, S. cerevisiae, homolog of antibody|decapping enzyme homolog (S. cerevisiae) antibody|FLJ33245 antibody|hDpc antibody|m7GpppN-mRNA hydrolase antibody|mRNA decapping enzyme 2 antibody|mRNA-decapping enzyme 2 antibody|Nucleoside diphosphate-linked moiety X motif 20 antibody|nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody|Nudix motif 20 antibody|NUDT20 antibody
Anti-Dcp2 antibody (ab28658)
Close sc-368179|sc-133650|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DCP2 Antibody

Catalogue No.

CSB-PA810265ESR1HU

Reactivity

Human

Immunogen

Recombinant human m7GpppN-mRNA hydrolase protein (1-240AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

48 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:167227( Human), Entrez Gene:70640( Mouse), Omim:609844( Human), SwissProt:Q8IU60( Human), SwissProt:Q9CYC6( Mouse), Unigene:443875( Human), Unigene:87629( Mouse)

Protein function

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5′-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). .

Protein tissue specificity

Expressed in brain and testis. Not detected in heart (at protein level). .

Protein sequence and domain

Belongs to the Nudix hydrolase family. DCP2 subfamily.

Protein post-translational modifications

Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).

Protein cellular localization

Cytoplasm, P-body . Nucleus . Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322). .

Research area

All research areas>Signaling Intermediates>hDcp
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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