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Rabbit Anti-DCP2 Antibody (CSB-PA810265ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Nucleoside diphosphate-linked moiety X motif 20 Antibody,Nudix motif 20 Antibody,mRNA-decapping enzyme 2 Antibody,hDpc Antibody,DCP2 Antibody,NUDT20 AntibodyMore alternative names for the antibody
DCP2 antibody|DCP2 decapping enzyme homolog (S. cerevisiae) antibody|DCP2, S. cerevisiae, homolog of antibody|DCP2_HUMAN antibody|decapping enzyme 2, S. cerevisiae, homolog of antibody|decapping enzyme homolog (S. cerevisiae) antibody|FLJ33245 antibody|hDpc antibody|m7GpppN-mRNA hydrolase antibody|mRNA decapping enzyme 2 antibody|mRNA-decapping enzyme 2 antibody|Nucleoside diphosphate-linked moiety X motif 20 antibody|nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody|Nudix motif 20 antibody|NUDT20 antibody
Anti-Dcp2 antibody (ab28658)
Anti-Dcp2 antibody (ab28658)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human m7GpppN-mRNA hydrolase protein (1-240AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5′-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). .
|Protein tissue specificity|| |
Expressed in brain and testis. Not detected in heart (at protein level). .
|Protein sequence and domain|| |
Belongs to the Nudix hydrolase family. DCP2 subfamily.
|Protein post-translational modifications|| |
Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).
|Protein cellular localization|| |
Cytoplasm, P-body . Nucleus . Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322). .
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CUSABIO BIOTECH CO.
|Product type|| |
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