Anti-DDX5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DDX5 Antibody (CSB-PA006630ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

DEAD box protein 5 Antibody,RNA helicase p68 Antibody,DDX5 Antibody,G17P1 Antibody, HELR Antibody, HLR1 Antibody

More alternative names for the antibody
ATP dependent RNA helicase DDX5 antibody|DDX 5 antibody|Ddx5 antibody|DDX5_HUMAN antibody|DEAD (Asp Glu Ala Asp) box helicase 5 antibody|DEAD (Asp Glu Ala Asp) box polypeptide 5 antibody|DEAD box 5 antibody|DEAD box protein 5 antibody|DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) antibody|G17P1 antibody|HELR antibody|HLR1 antibody|HUMP68 antibody|P68 antibody|p68 RNA helicase antibody|Probable ATP dependent RNA helicase DDX5 antibody|Probable ATP-dependent RNA helicase DDX5 antibody|RNA helicase p68 antibody
Anti-DDX5 antibody (ab21696)
Close sc-166167|sc-26045|sc-365164|sc-32858|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DDX5 Antibody

Catalogue No.

CSB-PA006630ESR2HU

Reactivity

Human

Immunogen

Recombinant human Probable ATP-dependent RNA helicase DDX5 protein (1-290AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:500-2000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

69 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1655( Human), Entrez Gene:13207( Mouse), Entrez Gene:287765( Rat), Omim:180630( Human), SwissProt:P17844( Human), SwissProt:Q61656( Mouse), Unigene:279806( Human), Unigene:220038( Mouse), Unigene:162208( Rat)

Protein function

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3′ transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. .

Protein sequence and domain

Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

Protein post-translational modifications

Arg-502 is dimethylated, probably to asymmetric dimethylarginine.; Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination. .; Polyubiquitinated, leading to proteasomal degradation. .

Protein cellular localization

Nucleus, nucleolus .

Research area

All research areas>Transcription Regulators>p68 RNA Helicase
(View all antibody categories related to Transcription Regulators)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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