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Rabbit Anti-DEDD2 Antibody (CSB-PA837874ESR2HU)
Supplier: CUSABIO BIOTECH CO.
DED-containing protein FLAME-3 Antibody,FADD-like anti-apoptotic molecule 3 Antibody,DEDD2 Antibody,FLAME3 AntibodyMore alternative names for the antibody
Death effector domain containing 2 antibody|Death effector domain-containing DNA-binding protein antibody|Death effector domain-containing protein antibody|Death effector domain-containing testicular protein antibody|DED containing protein FLAME 3 antibody|DEFT antibody|DNA binding death effector domain containing protein 2 antibody|DNA-binding death effector domain-containing protein 2 antibody|FADD like anti apoptotic molecule 3 antibody|FLAME 3 antibody
Anti-DEDD2 antibody (ab36858)
Anti-DEDD2 antibody (ab36858)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human DNA-binding death effector domain-containing protein 2 protein (1-240AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:162989( Human), Entrez Gene:67379( Mouse), Entrez Gene:687118( Rat), Omim:606841( Human), SwissProt:Q8WXF8( Human), SwissProt:Q8QZV0( Mouse), Unigene:515432( Human), Unigene:280594( Mouse)
|Protein function|| |
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
|Protein tissue specificity|| |
Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt’s lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. .
|Protein sequence and domain|| |
Interactions with CASP8 and CASP10 are mediated by the DED domain.
|Protein cellular localization|| |
Nucleus, nucleolus . Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
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CUSABIO BIOTECH CO.
|Product type|| |
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