Anti-DEDD2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DEDD2 Antibody (CSB-PA837874ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

DED-containing protein FLAME-3 Antibody,FADD-like anti-apoptotic molecule 3 Antibody,DEDD2 Antibody,FLAME3 Antibody

More alternative names for the antibody
Death effector domain containing 2 antibody|Death effector domain-containing DNA-binding protein antibody|Death effector domain-containing protein antibody|Death effector domain-containing testicular protein antibody|DED containing protein FLAME 3 antibody|DEFT antibody|DNA binding death effector domain containing protein 2 antibody|DNA-binding death effector domain-containing protein 2 antibody|FADD like anti apoptotic molecule 3 antibody|FLAME 3 antibody
Anti-DEDD2 antibody (ab36858)
Close sc-79431|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DEDD2 Antibody

Catalogue No.

CSB-PA837874ESR2HU

Reactivity

Human

Immunogen

Recombinant human DNA-binding death effector domain-containing protein 2 protein (1-240AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

36 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:162989( Human), Entrez Gene:67379( Mouse), Entrez Gene:687118( Rat), Omim:606841( Human), SwissProt:Q8WXF8( Human), SwissProt:Q8QZV0( Mouse), Unigene:515432( Human), Unigene:280594( Mouse)

Protein function

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Protein tissue specificity

Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt’s lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels. .

Protein sequence and domain

Interactions with CASP8 and CASP10 are mediated by the DED domain.

Protein cellular localization

Nucleus, nucleolus . Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.

Research area

All research areas>Tumor Suppressor/Apoptosis>DEDD
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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