Anti-DFNA5 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DFNA5 Antibody (CSB-PA006766ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Inversely correlated with estrogen receptor expression 1 Antibody,ICERE-1 Antibody,DFNA5 Antibody,ICERE1 Antibody

More alternative names for the antibody
2310037D07Rik antibody|Non-syndromic hearing impairment protein 5 antibody|Nonsyndromic hearing impairment protein antibody
Anti-DFNA5 antibody – N-terminal (ab175614)
Close sc-79231|sc-79232|sc-393162|sc-366609|sc-79233|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DFNA5 Antibody

Catalogue No.

CSB-PA006766ESR2HU

Reactivity

Human

Immunogen

Recombinant human Non-syndromic hearing impairment protein 5 protein (1-260AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

54 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1687( Human), Omim:608798( Human), SwissProt:O60443( Human), Unigene:520708( Human)

Protein function

Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (PubMed:16897187, PubMed:18223688, PubMed:21522185). The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable). .

Protein tissue specificity

Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.

Involvement in disease

Deafness, autosomal dominant, 5 (DFNA5) [MIM:600994]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Is a tumor suppressor gene with an important role in colorectal cancer (CRC). .

Protein sequence and domain

Belongs to the gasdermin family. Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.

Protein cellular localization

Cytoplasm, cytosol . Cell membrane .

Research area

All research areas>Tumor Suppressor/Apoptosis>DFNA5
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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