Anti-DHCR24 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DHCR24 Antibody (CSB-PA618005ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

24-dehydrocholesterol reductase Antibody,3-beta-hydroxysterol delta-24-reductase Antibody,Diminuto/dwarf1 homolog Antibody,Seladin-1 Antibody,DHCR24 Antibody

More alternative names for the antibody
24 dehydrocholesterol reductase antibody|24-dehydrocholesterol reductase antibody|3 beta hydroxysterol delta 24 reductase antibody|3-beta-hydroxysterol delta-24-reductase antibody|DCE antibody|Delta(24)-sterol reductase antibody|Desmosterol to cholesterol enzyme antibody|DHC24_HUMAN antibody|Dhcr24 antibody|Diminuto dwarf1 homolog antibody|Diminuto/dwarf1 homolog antibody|KIAA0018 antibody|Nbla03646 antibody|Seladin-1 antibody|SELADIN1 antibody|Selective AD indicator 1 antibody|Selective Alzheimer’s Disease Indicator 1 antibody
Anti-Seladin 1 antibody (ab40490)
Close sc-398938|sc-390037|sc-48477|

Recommended applications: ELISA, WB, IHC

Recommended dilution: Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DHCR24 Antibody

Catalogue No.

CSB-PA618005ESR2HU

Reactivity

Human

Immunogen

Recombinant human Delta (24)-sterol reductase protein (227-516AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

Recommended dilution:WB:1:200-1000,IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

60 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1718( Human), Entrez Gene:74754( Mouse), Entrez Gene:298298( Rat), Omim:606418( Human), SwissProt:Q15392( Human), SwissProt:Q8VCH6( Mouse), SwissProt:Q5BQE6( Rat), Unigene:498727( Human), Unigene:133370( Mouse), Unigene:225146( Rat)

Protein function

Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. .

Protein tissue specificity

Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. .

Involvement in disease

Desmosterolosis (DESMOS) [MIM:602398]: Rare autosomal recessive disorder characterized by multiple congenital anomalies and elevated levels of the cholesterol precursor desmosterol in plasma, tissue, and cultured cells. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the FAD-binding oxidoreductase/transferase type 4 family.

Protein cellular localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Research area

All research areas>Synthesis and Degradation>DHCR
(View all antibody categories related to Synthesis and Degradation)

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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