Anti-DHDDS Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DHDDS Antibody (CSB-PA006845ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Dehydrodolichyl diphosphate synthase complex subunit DHDDSCurated Antibody,Cis-isoprenyltransferase Antibody,CIT Antibody,Cis-IPTase Antibody,Epididymis tissue protein Li 189m Antibody,DHDDS Antibody,HDS Antibody

More alternative names for the antibody
cis-IPTase antibody|Cis-isoprenyltransferase antibody|cis-prenyl transferase antibody|CIT antibody|CPT antibody|Dedol PP synthase antibody|dedol-PP synthase antibody|dehydrodolichyl diphosphate synthase antibody|DHDDS antibody|DS antibody|Epididymis tissue protein Li 189m antibody|HDS antibody|RP3-476K8.2 antibody|RP59 antibody
Anti-Dehydrodolichyl Diphosphate Synthase antibody – C-terminal (ab179730)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DHDDS Antibody

Catalogue No.

CSB-PA006845ESR2HU

Reactivity

Human

Immunogen

Recombinant human Dehydrodolichyl diphosphate synthase complex subunit DHDDS protein (1-333AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

38 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:523264( Cow), Entrez Gene:612157( Dog), Entrez Gene:100729457( Guinea pig), Entrez Gene:100057242( Horse), Entrez Gene:79947( Human), Entrez Gene:67422( Mouse), Entrez Gene:298541( Rat), Omim:608172( Human), SwissProt:Q86SQ9( Human), SwissProt:Q99KU1( Mouse), Unigene:369385( Human)

Protein function

With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. .

Protein tissue specificity

Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus. .

Involvement in disease

Retinitis pigmentosa 59 (RP59) [MIM:613861]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the UPP synthase family.

Protein cellular localization

Endoplasmic reticulum membrane ; Peripheral membrane protein . Note=colocalizes with calnexin.

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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