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Rabbit Anti-DHX58 Antibody (CSB-PA822187ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Probable ATP-dependent helicase LGP2 Antibody,Protein D11Lgp2 homolog Antibody,RIG-I-like receptor 3 Antibody,RLR-3 Antibody,RIG-I-like receptor LGP2 Antibody, RLR Antibody,DHX58 Antibody,D11LGP2E Antibody, LGP2 AntibodyMore alternative names for the antibody
D11LGP2 antibody|D11lgp2e antibody|DEXH (Asp Glu X His) box polypeptide 58 antibody|DEXH box polypeptide 58 antibody|DHX 58 antibody|DHX58 antibody|DHX58_HUMAN antibody|LGP 2 antibody|LGP2 antibody|Ortholog of mouse D11lgp2 antibody|Probable ATP dependent helicase LGP2 antibody|Probable ATP dependent RNA helicase DHX58 antibody|Probable ATP-dependent helicase LGP2 antibody|Probable ATP-dependent RNA helicase DHX58 antibody|Protein D11Lgp2 homolog antibody|RIG-I-like receptor LGP2 antibody|RLR antibody|RNA helicase LGP2 antibody
Anti-DHX58 antibody (ab67270)
Anti-DHX58 antibody (ab67270)
Recommended applications: ELISA, WB, IHC
Recommended dilution: Recommended dilution:WB:1:500-2000,IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Probable ATP-dependent RNA helicase DHX58 protein (389-678AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:79132( Human), Entrez Gene:80861( Mouse), Entrez Gene:303538( Rat), Omim:608588( Human), SwissProt:Q96C10( Human), SwissProt:Q99J87( Mouse), Unigene:55918( Human), Unigene:271830( Mouse), Unigene:105654( Rat)
|Protein function|| |
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5′-triphosphorylated RNA, although it can recognize RNA lacking a 5′-triphosphate. .
|Protein sequence and domain|| |
Belongs to the helicase family. RLR subfamily. The RLR CTR domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.
|Protein cellular localization|| |
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|Product type|| |
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