Anti-DIAPH2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DIAPH2 Antibody (CSB-PA006891ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Protein diaphanous homolog 2 Antibody,Diaphanous-related formin-2 Antibody,DRF2 Antibody,DIAPH2 Antibody,DIA Antibody

More alternative names for the antibody
Dia 2 antibody|Diaphanous2 antibody|Diaphorase 2 antibody|Diaphorase2 antibody|DRF 2 antibody|DRF2 antibody|FLJ11167 antibody|OTTHUMP00000024270 antibody|OTTHUMP00000024271 antibody|OTTHUMP00000062171 antibody|POF 2 antibody|POF antibody|POF2 antibody|Protein diaphanous homolog 2 antibody
Anti-DIAPH2 antibody [EPR13158] (ab181165)
Close sc-55539|sc-393499|sc-10889|sc-55540|sc-28776|sc-393489|sc-10894|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-DIAPH2 Antibody

Catalogue No.

CSB-PA006891ESR1HU

Reactivity

Human

Immunogen

Recombinant human Protein diaphanous homolog 2 protein (1-120AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

125 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1730( Human), Entrez Gene:54004( Mouse), Entrez Gene:317189( Rat), Omim:300108( Human), SwissProt:O60879( Human), SwissProt:O70566( Mouse), Unigene:226483( Human), Unigene:10763( Mouse)

Protein function

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. .

Protein tissue specificity

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

Involvement in disease

Premature ovarian failure 2A (POF2A) [MIM:300511]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the formin homology family. Diaphanous subfamily. The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).

Protein cellular localization

Isoform 3: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

Research area

All research areas>Kinases and Phosphatases>Dia
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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