Anti-DKK4 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DKK4 Antibody (CSB-PA883367ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Dickkopf-4 Antibody,Dkk-4 Antibody, hDkk-4 Antibody,DKK4 Antibody

More alternative names for the antibody
Dickkopf 4 antibody|Dickkopf-4 antibody|Dickkopf4 antibody|DKK 4 antibody|Dkk-4 antibody|DKK4 antibody|DKK4_HUMAN antibody|hDkk 4 antibody|hDkk-4 antibody|hDkk4 antibody|MGC129562 antibody|MGC129563 antibody
Anti-DKK4 antibody [EPR7867(2)] (ab172613)
Close sc-14962|sc-25519|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DKK4 Antibody

Catalogue No.

CSB-PA883367ESR1HU

Reactivity

Human

Immunogen

Recombinant human Dickkopf-related protein 4 protein (19-224AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

24 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:27121( Human), Entrez Gene:234130( Mouse), Entrez Gene:502097( Rat), GenBank:NP_055235.1( Human), Omim:605417( Human), SwissProt:Q9UBT3( Human), SwissProt:Q8VEJ3( Mouse), Unigene:159311( Human), Unigene:157322( Mouse)

Protein function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .

Protein tissue specificity

Expressed in cerebellum, T-cells, esophagus and lung.

Protein sequence and domain

Belongs to the dickkopf family. The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.

Protein post-translational modifications

Appears to be not glycosylated.; Can be proteolytically processed by a furin-like protease. .

Protein cellular localization

Secreted.

Research area

All research areas>Signaling Intermediates>Dkk
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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