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Rabbit Anti-DNAJB2 Antibody (CSB-PA007008DSR1HU)
Supplier: CUSABIO BIOTECH CO.
DnaJ homolog subfamily B member 2 Antibody,DnaJ protein homolog 1 Antibody,Heat shock 40 kDa protein 3 Antibody,Heat shock protein J1 Antibody,HSJ-1 Antibody,DNAJB2 Antibody,HSJ1 Antibody,HSPF3 AntibodyMore alternative names for the antibody
Descriptions antibody|DnaJ (Hsp40) homolog subfamily B member 2 antibody|DnaJ homolog subfamily B member 2 antibody|DnaJ protein homolog 1 antibody|DNAJB2 antibody|Heat shock 40 kDa protein 3 antibody|Heat shock protein J1 antibody|Heat shock protein neuronal DNAJ like 1 antibody|HSJ 1 antibody|HSJ1 antibody|HSPF3 antibody
Anti-DNAJB2 antibody (ab77322)
Anti-DNAJB2 antibody (ab77322)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human DnaJ homolog subfamily B member 2 protein (215-324AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3300" target="_blank">Entrez Gene:3300( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/604139" target="_blank">Omim:604139( Human)</a>, <a href="http://www.uniprot.org/uniprot/P25686" target="_blank">SwissProt:P25686( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=77768" target="_blank">Unigene:77768( Human)</a>
|Protein function|| |
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PARK2, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). .
|Protein tissue specificity|| |
More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272). .
|Involvement in disease|| |
Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The J domain is sufficient to interact with HSP70 (HSPA1A or HSPA1B) and activate its ATPase activity (PubMed:22219199). The J domain is also required for the HSP70-mediated and ubiquitin-dependent proteasomal degradation of proteins like ATXN3 (PubMed:21625540). The J domain is required to reduce PARK2 cytoplasmic aggregation (PubMed:20889486).; The UIM domains mediate interaction with ubiquitinated chaperone clients and with the proteasome (PubMed:15936278). The UIM domains may have an opposite activity to the J domain, binding ubiquitinated proteins and protecting them from HSP70-mediated proteasomal degradation (PubMed:21625540). The UIM domains are not required to reduce PARK2 cytoplasmic aggregation (PubMed:20889486).
|Protein post-translational modifications|| |
Ubiquitinated by STUB1; does not lead to proteasomal degradation. .
|Protein cellular localization|| |
Isoform 2: Cytoplasm . Nucleus .; Isoform 1: Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .
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|Product type|| |
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