Anti-DNAJB2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DNAJB2 Antibody (CSB-PA007008DSR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

DnaJ homolog subfamily B member 2 Antibody,DnaJ protein homolog 1 Antibody,Heat shock 40 kDa protein 3 Antibody,Heat shock protein J1 Antibody,HSJ-1 Antibody,DNAJB2 Antibody,HSJ1 Antibody,HSPF3 Antibody

More alternative names for the antibody
Descriptions antibody|DnaJ (Hsp40) homolog subfamily B member 2 antibody|DnaJ homolog subfamily B member 2 antibody|DnaJ protein homolog 1 antibody|DNAJB2 antibody|Heat shock 40 kDa protein 3 antibody|Heat shock protein J1 antibody|Heat shock protein neuronal DNAJ like 1 antibody|HSJ 1 antibody|HSJ1 antibody|HSPF3 antibody
Anti-DNAJB2 antibody (ab77322)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-DNAJB2 Antibody

Catalogue No.

CSB-PA007008DSR2HU

Reactivity

Human

Immunogen

Recombinant human DnaJ homolog subfamily B member 2 protein (215-324AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

35 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:3300( Human), Omim:604139( Human), SwissProt:P25686( Human), Unigene:77768( Human)

Protein function

Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PARK2, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). .

Protein tissue specificity

More abundantly expressed in neocortex, cerebellum, spinal cord and retina where it is expressed by neuronal cells (at protein level) (PubMed:1599432, PubMed:12754272). Detected at much lower level in non-neuronal tissues including kidney, lung, heart, skeletal muscle, spleen and testis (at protein level) (PubMed:12754272, PubMed:1599432). Isoform 1 is more abundant in neocortex and cerebellum compared to isoform 2 (at protein level) (PubMed:12754272). .

Involvement in disease

Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The J domain is sufficient to interact with HSP70 (HSPA1A or HSPA1B) and activate its ATPase activity (PubMed:22219199). The J domain is also required for the HSP70-mediated and ubiquitin-dependent proteasomal degradation of proteins like ATXN3 (PubMed:21625540). The J domain is required to reduce PARK2 cytoplasmic aggregation (PubMed:20889486).; The UIM domains mediate interaction with ubiquitinated chaperone clients and with the proteasome (PubMed:15936278). The UIM domains may have an opposite activity to the J domain, binding ubiquitinated proteins and protecting them from HSP70-mediated proteasomal degradation (PubMed:21625540). The UIM domains are not required to reduce PARK2 cytoplasmic aggregation (PubMed:20889486).

Protein post-translational modifications

Ubiquitinated by STUB1; does not lead to proteasomal degradation. .

Protein cellular localization

Isoform 2: Cytoplasm . Nucleus .; Isoform 1: Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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