Anti-DNAJC2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DNAJC2 Antibody (CSB-PA858715ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

M-phase phosphoprotein 11 Antibody,Zuotin-related factor 1 Antibody,DNAJC2 Antibody,MPHOSPH11 Antibody, MPP11 Antibody,ZRF1 Antibody

More alternative names for the antibody
AU020218 antibody|
Anti-DNAJC2 antibody (ab134572)
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Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DNAJC2 Antibody

Catalogue No.

CSB-PA858715ESR2HU

Reactivity

Human

Immunogen

Recombinant human DnaJ homolog subfamily C member 2 protein (1-140AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

71 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:507897( Cow), Entrez Gene:27000( Human), Entrez Gene:22791( Mouse), Entrez Gene:116456( Rat), Omim:605502( Human), SwissProt:Q1RMH9( Cow), SwissProt:Q99543( Human), SwissProt:P54103( Mouse), SwissProt:Q7TQ20( Rat), Unigene:558476( Human), Unigene:266312( Mouse), Unigene:11908( Rat)

Protein function

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at ‘Lys-119′ (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5′-GTCAAGC-3’. .

Protein tissue specificity

Widely expressed. .

Protein sequence and domain

The ZRF1-UBD region specifically recognizes and binds H2AK119ub. The ZRF1-UBD region is also involved in protein-protein interactions with other proteins, suggesting that it may be masked by some regulator, thereby preventing its association with H2AK119ub.

Protein post-translational modifications

Phosphorylated in M (mitotic) phase. .

Protein cellular localization

Nucleus . Cytoplasm, cytosol .

Research area

All research areas>Signaling Intermediates>Zuotin
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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