Anti-DOCK8 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Anti-DOCK8 Antibody (CSB-PA836734ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Dedicator of cytokinesis protein 8 Antibody,DOCK8 Antibody

More alternative names for the antibody
1200017A24Rik antibody|Dedicator of cytokinesis protein 8 antibody|DOCK8 antibody|DOCK8_HUMAN antibody|Epididymis luminal protein 205 antibody|HEL 205 antibody|MRD2 antibody|ZIR8 antibody
Anti-DOCK8 antibody [EPR12511] (ab175208)
Close sc-376911|sc-292124|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DOCK8 Antibody

Catalogue No.

CSB-PA836734ESR1HU

Reactivity

Human

Immunogen

Recombinant human Dedicator of cytokinesis protein 8 protein (1900-2099AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

238 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:81704( Human), Omim:611432( Human), SwissProt:Q8NF50 ( Human), Unigene:132599( Human)

Protein function

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (By similarity). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). .

Involvement in disease

Hyperimmunoglobulin E recurrent infection syndrome, autosomal recessive (AR-HIES) [MIM:243700]: A rare disorder characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Mental retardation, autosomal dominant 2 (MRD2) [MIM:614113]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. . Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. A balanced translocation, t(X;9) (q13.1;p24). A genomic deletion of approximately 230 kb in subtelomeric 9p has been detected in a patient with mental retardation.

Protein sequence and domain

Belongs to the DOCK family. The DHR-2 domain may mediate some GEF activity.

Research area

All research areas>Signaling Intermediates>DOCK 8
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!