Anti-DUOX2 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-DUOX2 Antibody (CSB-PA007229ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Dual oxidase 2 Antibody,Large NOX 2 Antibody,Long NOX 2 Antibody,NADH/NADPH thyroid oxidase p138-tox Antibody,NADPH oxidase/peroxidase DUOX2 Antibody,NADPH thyroid oxidase 2 Antibody,Thyroid oxidase 2 Antibody,p138 thyroid oxidase Antibody,DUOX2 Antibody,LNOX2 Antibody,THOX2 Antibody

More alternative names for the antibody
Dual oxidase 2 antibody|Dual oxidase like domains 2 antibody|Dual oxidase2 antibody|DUOX2 antibody|DUOX2_HUMAN antibody|Flavoprotein NADPH oxidase antibody|Large NOX 2 antibody|LNOX2 antibody|Long NOX 2 antibody|NADH/NADPH thyroid oxidase p138 tox antibody|NADH/NADPH thyroid oxidase p138-tox antibody|NADPH oxidase/peroxidase DUOX2 antibody|NADPH thyroid oxidase 2 antibody|Nicotinamide adenine dinucleotide phosphate oxidase antibody|NOXEF2 antibody|p138 thyroid oxidase antibody|P138 TOX antibody|TDH6 antibody|THOX2 antibody|Thyroid oxidase 2 antibody
Anti-DUOX2 antibody (ab65813)
Close sc-398681|sc-49939|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-DUOX2 Antibody

Catalogue No.

CSB-PA007229ESR2HU

Reactivity

Human

Immunogen

Recombinant human Dual oxidase 2 protein (1-100AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

175 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:50506( Human), Entrez Gene:214593( Mouse), Entrez Gene:79107( Rat), Omim:606759( Human), SwissProt:Q9NRD8( Human), SwissProt:Q9ES45( Rat), Unigene:71377( Human), Unigene:358846( Mouse), Unigene:55542( Rat)

Protein function

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. .

Protein tissue specificity

Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. .

Involvement in disease

Thyroid dyshormonogenesis 6 (TDH6) [MIM:607200]: A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Defects in DUOX2 may play a role in the pathogenesis of very early onset inflammatory bowel disease (VEOIBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology diagnosed before 6 years of age. VEOIBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but the phenotype of children with onset of Crohn disease occurring younger than the age of 10 is predominantly colonic, with a lower risk of ileal disease. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. .

Protein sequence and domain

In the N-terminal section; belongs to the peroxidase family.

Protein post-translational modifications

N-glycosylated. .

Protein cellular localization

Apical cell membrane ; Multi-pass membrane protein . Cell junction . Note=Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens, such as Escherichia coli. .

Research area

All research areas>Synthesis and Degradation>DUOX
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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