Anti-EFHC1 Antibody

$99.00$319.00

Reactivity: Human,Mouse
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-EFHC1 Antibody (CSB-PA708490ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

EF-hand domain-containing protein 1 Antibody,Myoclonin-1 Antibody,EFHC1 Antibody

More alternative names for the antibody
EF hand domain (C terminal) containing 1 antibody|EF hand domain containing protein 1 antibody|EF-hand domain-containing protein 1 antibody|Efhc1 antibody|EFHC1_HUMAN antibody|EJA1 antibody|EJM1 antibody|FLJ10466 antibody|FLJ37290 antibody|JAE antibody|Myoclonin 1 antibody|Myoclonin-1 antibody
Anti-EFHC1 antibody – N-terminal (ab178366)
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Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-EFHC1 Antibody

Catalogue No.

CSB-PA708490ESR1HU

Reactivity

Human, Mouse

Immunogen

Recombinant human EF-hand domain-containing protein 1 protein (391-640AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

73 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:510124 ( Cow), Entrez Gene:474935 ( Dog), Entrez Gene:100736135( Guinea pig), Entrez Gene:100069174( Horse), Entrez Gene:114327( Human), Entrez Gene:71877( Mouse), Entrez Gene:100152550( Pig), Entrez Gene:100352671( Rabbit), Entrez Gene:301295( Rat), Omim:608815( Human), SwissProt:Q5JVL4( Human), SwissProt:Q9D9T8( Mouse), Unigene:403171( Human), Unigene:29178( Mouse), Unigene:198826( Rat)

Protein function

Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581). .

Protein tissue specificity

Widely expressed. Not detected in lymphocytes. .

Involvement in disease

Juvenile myoclonic epilepsy 1 (EJM1) [MIM:254770]: A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Juvenile absence epilepsy 1 (JAE1) [MIM:607631]: A subtype of idiopathic generalized epilepsy characterized by onset occurring around puberty, absence seizures, generalized tonic-clonic seizures (GTCS), GTCS on awakening, and myoclonic seizures. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Note=Mutation Leu-229 may be a cause of intractable epilepsy of infancy. Affected individuals have seizures of multiple type, manifested as tonic, clonic, and myoclonic seizures in the neonatal period, and as tonic seizures activated frequently by sleep, and repeated frequent myoclonic seizures in later infancy. The seizures are unresponsive to numerous antiepileptic drugs, and infants die in the first years of life. Although heterozygosity for Leu-229 has been associated with relatively benign forms of epilepsy in adolescence, homozygosity for the same mutation has much more severe consequences. .

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle .

Note

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Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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