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Rabbit Anti-EFNA1 Antibody (CSB-PA007460ESR1HU)
Supplier: CUSABIO BIOTECH CO.
EPH-related receptor tyrosine kinase ligand 1 Antibody,LERK-1 Antibody,Immediate early response protein B61 Antibody,Tumor necrosis factor alpha-induced protein 4 Antibody,TNF alpha-induced protein 4 Antibody,EFNA1 Antibody,EPLG1 Antibody, LERK1 Antibody, TNFAIP4 AntibodyMore alternative names for the antibody
B61 antibody|OTTHUMP00000033242 antibody|OTTHUMP00000033271 antibody|secreted form antibody|TNF alpha-induced protein 4 antibody|TNFAIP 4 antibody|TNFAIP4 antibody|Tumor necrosis factor alpha induced protein 4 antibody|Tumor necrosis factor alpha-induced protein 4 antibody
Anti-Ephrin A1 antibody (ab199697)
Anti-Ephrin A1 antibody (ab199697)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Ephrin-A1 protein (19-182AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:1942( Human), Entrez Gene:13636( Mouse), Entrez Gene:94268( Rat), Omim:191164( Human), SwissProt:P20827( Human), SwissProt:P52793( Mouse), SwissProt:P97553( Rat), Unigene:516664( Human), Unigene:15675( Mouse), Unigene:8427( Rat)
|Protein function|| |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. .
|Protein tissue specificity|| |
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). .
|Protein sequence and domain|| |
Belongs to the ephrin family.
|Protein post-translational modifications|| |
Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.; N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization. .
|Protein cellular localization|| |
Cell membrane ; Lipid-anchor, GPI-anchor .; Ephrin-A1, secreted form: Secreted .
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CUSABIO BIOTECH CO.
|Product type|| |
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