Anti-EFNA1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-EFNA1 Antibody (CSB-PA007460ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

EPH-related receptor tyrosine kinase ligand 1 Antibody,LERK-1 Antibody,Immediate early response protein B61 Antibody,Tumor necrosis factor alpha-induced protein 4 Antibody,TNF alpha-induced protein 4 Antibody,EFNA1 Antibody,EPLG1 Antibody, LERK1 Antibody, TNFAIP4 Antibody

More alternative names for the antibody
B61 antibody|OTTHUMP00000033242 antibody|OTTHUMP00000033271 antibody|secreted form antibody|TNF alpha-induced protein 4 antibody|TNFAIP 4 antibody|TNFAIP4 antibody|Tumor necrosis factor alpha induced protein 4 antibody|Tumor necrosis factor alpha-induced protein 4 antibody
Anti-Ephrin A1 antibody (ab199697)
Close sc-377362|sc-377165|sc-20719|sc-911|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-EFNA1 Antibody

Catalogue No.

CSB-PA007460ESR1HU

Reactivity

Human

Immunogen

Recombinant human Ephrin-A1 protein (19-182AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

23 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:1942( Human), Entrez Gene:13636( Mouse), Entrez Gene:94268( Rat), Omim:191164( Human), SwissProt:P20827( Human), SwissProt:P52793( Mouse), SwissProt:P97553( Rat), Unigene:516664( Human), Unigene:15675( Mouse), Unigene:8427( Rat)

Protein function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. .

Protein tissue specificity

Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). .

Protein sequence and domain

Belongs to the ephrin family.

Protein post-translational modifications

Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.; N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization. .

Protein cellular localization

Cell membrane ; Lipid-anchor, GPI-anchor .; Ephrin-A1, secreted form: Secreted .

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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