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Rabbit Anti-EIF2S3 Antibody (CSB-PA007528ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Eukaryotic translation initiation factor 2 subunit 3 Antibody,Eukaryotic translation initiation factor 2 subunit gamma X Antibody,eIF-2-gamma X Antibody,eIF-2gX Antibody,EIF2S3 Antibody,EIF2G AntibodyMore alternative names for the antibody
eIF-2-gamma X antibody|eIF-2gA antibody|eIF-2gX antibody|EIF2 antibody|EIF2G antibody|EIF2gamma antibody|EIF2S3 antibody|Eukaryotic translation initiation factor 2 gamma antibody|Eukaryotic translation initiation factor 2 gamma subunit antibody|Eukaryotic translation initiation factor 2 subunit 3 antibody|Eukaryotic translation initiation factor 2 subunit 3 gamma 52kDa antibody|Eukaryotic translation initiation factor 2 subunit gamma X antibody|IF2G_HUMAN antibody
Anti-EIF2G antibody (ab33207)
Anti-EIF2G antibody (ab33207)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Eukaryotic translation initiation factor 2 subunit 3 protein (173-472AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:1968( Human), Entrez Gene:26905( Mouse), Entrez Gene:26908( Mouse), Entrez Gene:100312984( Rat), Entrez Gene:299027( Rat), Omim:300161( Human), SwissProt:P41091( Human), SwissProt:Q9Z0N1( Mouse), SwissProt:P81795( Rat), Unigene:539684( Human), Unigene:218851( Mouse), Unigene:250909( Mouse), Unigene:220237( Rat), Unigene:87025( Rat)
|Protein function|| |
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). .
|Protein tissue specificity|| |
Expressed in testis, brain, liver and muscle. .
|Involvement in disease|| |
Mental retardation, X-linked, syndromic, Borck type (MRXSBRK) [MIM:300987]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSBRK patients manifest global developmental delay, short stature, microcephaly, poor or absent speech, and dysmorphic facial features. Additional features are growth hormone deficiency, hypogonadism, and spasticity resulting in difficulty walking or inability to walk. Thin corpus callosum and reduced white matter volume are observed on brain imaging. Inheritance is X-linked recessive. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
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CUSABIO BIOTECH CO.
|Product type|| |
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