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Rabbit Anti-EIF3E Antibody (CSB-PA007534ESR1HU)
Supplier: CUSABIO BIOTECH CO.
eIF3 Antibody,Eukaryotic translation initiation factor 3 subunit 6 Antibody,Viral integration site protein INT-6 homolog Antibody,eIF-3 p48 Antibody,EIF3E Antibody,EIF3S6 AntibodyMore alternative names for the antibody
eIF-3 p48 antibody|eIF3e antibody|EIF3E_HUMAN antibody|EIF3S6 antibody|eIFe antibody|Eukaryotic translation initiation factor 3 subunit 6 antibody|Eukaryotic translation initiation factor 3 subunit E antibody|eukaryotic translation initiation factor 3, subunit 6 (48kD) antibody|INT6 antibody|mammary tumor-associated protein INT6 antibody|murine mammary tumor integration site 6 (oncogene homolog) antibody|Viral integration site protein INT-6 homolog antibody
Anti-eIF3e antibody (ab36766)
Anti-eIF3e antibody (ab36766)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Eukaryotic translation initiation factor 3 subunit E protein (1-445AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:534165( Cow), Entrez Gene:3646( Human), Entrez Gene:16341( Mouse), Entrez Gene:299872( Rat), Omim:602210( Human), SwissProt:Q3T102( Cow), SwissProt:P60228( Human), SwissProt:P60229( Mouse), SwissProt:Q641X8( Rat), Unigene:405590( Human), Unigene:289992( Mouse), Unigene:98547( Rat)
|Protein function|| |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). .
|Protein tissue specificity|| |
Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. .
|Protein sequence and domain|| |
Belongs to the eIF-3 subunit E family.
|Protein cellular localization|| |
Cytoplasm. Nucleus, PML body.
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|Product type|| |
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