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Rabbit Anti-EIF3F Antibody (CSB-PA007535ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Eukaryotic translation initiation factor 3 subunit F Antibody,Deubiquitinating enzyme eIF3f Antibody,Eukaryotic translation initiation factor 3 subunit 5 Antibody,EIF3F AntibodyMore alternative names for the antibody
Deubiquitinating enzyme eIF3f antibody|eIF 3 epsilon antibody|eIF-3-epsilon antibody|eIF3 p47 antibody|eIF3 p47 subunit antibody|eIF3-epsilon antibody|eIF3-p47 antibody|eIF3f antibody|EIF3F_HUMAN antibody|EIF3S5 antibody|EIF3S5, formerly antibody|Eukaryotic translation initiation factor 3 subunit 5 antibody|Eukaryotic translation initiation factor 3 subunit 5, formerly antibody|Eukaryotic translation initiation factor 3 subunit F antibody|eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD) antibody|eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa antibody|eukaryotic translation initiation factor 3, subunit F antibody|translation initiation factor 3 47 kda subunit antibody
Anti-EIF3F antibody (ab64177)
Anti-EIF3F antibody (ab64177)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Eukaryotic translation initiation factor 3 subunit F protein (88-357AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
Entrez Gene:451007( Chimpanzee), Entrez Gene:8665( Human), Entrez Gene:66085( Mouse), Entrez Gene:293427( Rat), Omim:603914( Human), SwissProt:A5A6I3( Chimpanzee), SwissProt:Q4R5B8( Cynomolgus Monkey), SwissProt:O00303( Human), SwissProt:Q9DCH4( Mouse), Unigene:516023( Human), Unigene:182962( Mouse), Unigene:41724( Rat)
|Protein function|| |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). .; Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling. .
|Protein sequence and domain|| |
Belongs to the eIF-3 subunit F family. The MPN domain mediates deubiquitinating activity.
|Protein post-translational modifications|| |
Phosphorylation is enhanced upon serum stimulation. Phosphorylated during apoptosis by caspase-processed CDK11. .
|Protein cellular localization|| |
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|Product type|| |
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