Anti-EPHB1 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-EPHB1 Antibody (CSB-PA007729ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Ephrin type-B receptor 1 Antibody,ELK Antibody,EPH tyrosine kinase 2 Antibody,EPH-like kinase 6 Antibody,EK6 Antibody,hEK6 Antibody,Neuronally-expressed EPH-related tyrosine kinase Antibody,NET Antibody,Tyrosine-protein kinase receptor EPH-2 Antibody,EPHB1 Antibody,ELK Antibody,EPHT2 Antibody,HEK6 Antibody,NET Antibody

More alternative names for the antibody
EPH B1 antibody|EPH B2 antibody|Eph tyrosine kinase 2 antibody|Eph tyrosine kinase 3 antibody|EPHB1 antibody|EPHB2 antibody|Ephrin receptor EphB1 antibody|Ephrin receptor EphB2 antibody|Ephrin type B receptor 1 antibody|Ephrin type B receptor 2 antibody|EPHT 2 antibody|EPHT 3 antibody|ERK antibody|Hek 5 antibody|Hek 6 antibody|Tyrosine protein kinase receptor EPH2 antibody|Tyrosine protein kinase receptor EPH3 antibody
Phospho anti-Eph receptor B1 + Eph receptor B2 (Y594) antibody (ab61791)
Close sc-130752|sc-27107|sc-1763|sc-28980|sc-100298|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-EPHB1 Antibody

Catalogue No.

CSB-PA007729ESR2HU

Reactivity

Human

Immunogen

Recombinant human Ephrin type-B receptor 1 protein (260-500AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

109 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2047( Human), Entrez Gene:2048( Human), Entrez Gene:13844( Mouse), Entrez Gene:270190( Mouse), Entrez Gene:24338( Rat), Entrez Gene:313633( Rat), Omim:600600( Human), Omim:600997( Human), SwissProt:P29323( Human), SwissProt:P54762( Human), SwissProt:P54763( Mouse), SwissProt:Q8CBF3( Mouse), SwissProt:B2B9B0( Rat), SwissProt:P09759( Rat), Unigene:116092( Human), Unigene:523329( Human)

Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. .

Protein tissue specificity

Preferentially expressed in brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Protein post-translational modifications

Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. .; Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. .

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .

Research area

All research areas>Membrane Receptors>Eph
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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