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Rabbit Anti-ERBB3 Antibody (CSB-PA007765ESR1HU)
Supplier: CUSABIO BIOTECH CO.
Receptor tyrosine-protein kinase erbB-3 Antibody,Proto-oncogene-like protein c-ErbB-3 Antibody,Tyrosine kinase-type cell surface receptor HER3 Antibody,ERBB3 Antibody,HER3 AntibodyMore alternative names for the antibody
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Anti-ErbB 3 antibody [RTJ2] (ab20161)
Anti-ErbB 3 antibody [RTJ2] (ab20161)
Recommended applications: ELISA, IHC
Recommended dilution: Recommended dilution:IHC:1:20-1:200
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Receptor tyrosine-protein kinase erbB-3 protein (20-285AA)
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Protein function|| |
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). .
|Protein tissue specificity|| |
Epithelial tissues and brain.
|Involvement in disease|| |
Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
|Protein post-translational modifications|| |
Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). .
|Protein cellular localization|| |
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
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CUSABIO BIOTECH CO.
|Product type|| |
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