Anti-ERBB3 Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ERBB3 Antibody (CSB-PA007765ESR1HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

Receptor tyrosine-protein kinase erbB-3 Antibody,Proto-oncogene-like protein c-ErbB-3 Antibody,Tyrosine kinase-type cell surface receptor HER3 Antibody,ERBB3 Antibody,HER3 Antibody

More alternative names for the antibody
c erbB 3 antibody|c erbB3 antibody|Erb b2 receptor tyrosine kinase 3 antibody|ErbB 3 antibody|ERBB3 antibody|ERBB3 protein antibody|erbB3 S antibody|ERBB3_HUMAN antibody|Glial growth factor receptor antibody|HER 3 antibody|HER3 antibody|Human epidermal growth factor receptor 3 antibody|LCCS2 antibody|MDA BF 1 antibody|MGC88033 antibody|p180 ErbB3 antibody|p45 sErbB3 antibody|p85 sErbB3 antibody|proto-oncogene-like protein c ErbB 3 antibody|proto-oncogene-like protein c ErbB3 antibody|Proto-oncogene-like protein c-ErbB-3 antibody|Receptor tyrosine protein kinase erbB 3 antibody|Receptor tyrosine protein kinase erbB3 antibody|Receptor tyrosine-protein kinase erbB-3 antibody|Tyrosine kinase type cell surface receptor HER3 antibody|Tyrosine kinase-type cell surface receptor HER3 antibody|v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody|v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody|v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
Anti-ErbB 3 antibody [RTJ2] (ab20161)
Close sc-81454|sc-71067|sc-81455|sc-285|sc-292557|sc-415|sc-53279|sc-71071|

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols

Name

Anti-ERBB3 Antibody

Catalogue No.

CSB-PA007765ESR1HU

Reactivity

Human

Immunogen

Recombinant human Receptor tyrosine-protein kinase erbB-3 protein (20-285AA)

Host

Rabbit

Applications

ELISA, IHC

Recommended dilution

Recommended dilution:IHC:1:20-1:200

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

148 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:2065( Human), Omim:190151( Human), SwissProt:P21860( Human), Unigene:118681( Human)

Protein function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). .

Protein tissue specificity

Epithelial tissues and brain.

Involvement in disease

Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Protein post-translational modifications

Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). .

Protein cellular localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.

Research area

All research areas>Membrane Receptors>ErbB
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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