Anti-ERCC2 Antibody


Reactivity: Human
Applications: ELISA,IHC
Conjugation: Various

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Rabbit Anti-ERCC2 Antibody (CSB-PA007770ESR1HU)


Alternative names:

Basic transcription factor 2 80 kDa subunit Antibody,BTF2 p80 Antibody,CXPD Antibody,DNA excision repair protein ERCC-2 Antibody,DNA repair protein complementing XP-D cells Antibody,TFIIH basal transcription factor complex 80 kDa subunit Antibody,TFIIH 80 kDa subunit Antibody,TFIIH p80 Antibody,Xeroderma pigmentosum group D-complementing protein Antibody,ERCC2 Antibody,XPD Antibody, XPDC Antibody

More alternative names for the antibody
TFIIH 80 kDa subunit antibody|Basic transcription factor 2 80 kDa subunit antibody|BTF2 p80 antibody|COFS 2 antibody|COFS2 antibody|CXPD antibody|DNA excision repair protein ERCC 2 antibody|DNA excision repair protein ERCC-2 antibody|DNA repair protein complementing XP D cells antibody|DNA repair protein complementing XP-D cells antibody|EM9 antibody|ERCC 2 antibody|ERCC2 antibody|ERCC2_HUMAN antibody|Excision repair 2 antibody|Excision repair cross complementing rodent repair deficiency complementation antibody|Excision repair cross complementing rodent repair deficiency, complementation group 2 antibody|MAG antibody|MGC102762 antibody|MGC126218 antibody|MGC126219 antibody|OTTHUMP00000045860 antibody|OTTHUMP00000045861 antibody|OTTHUMP00000045862 antibody|OTTHUMP00000045863 antibody|TFIIH 80 kDa subunit antibody|TFIIH basal transcription factor complex 80 kDa subunit antibody|TFIIH Basal Transcription Factor Complex Helicase Subunit antibody|TFIIH basal transcription factor complex helicase XPD subunit antibody|TFIIH basal transcription factor complex p80 subunit antibody|TFIIH p80 antibody|TTD antibody|Xeroderma pigmentosum complementary group D antibody|Xeroderma pigmentosum group D complementing protein antibody|Xeroderma pigmentosum group D-complementing protein antibody|XPD antibody|XPDC antibody
Anti-XPD antibody (ab54676)

Recommended applications: ELISA, IHC

Recommended dilution: Recommended dilution:IHC:1:20-1:200

Recommended protocols: check protocols


Anti-ERCC2 Antibody

Catalogue No.





Recombinant human TFIIH basal transcription factor complex helicase XPD subunit protein (1-300AA)











Molecular weight

86 kDa


Antigen Affinity Purified


Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Protein function

ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. .

Involvement in disease

Xeroderma pigmentosum complementation group D (XP-D) [MIM:278730]: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. Some XP-D patients present features of Cockayne syndrome, including cachectic dwarfism, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. The phenotype combining xeroderma pigmentosum and Cockayne syndrome traits is referred to as XP-CS complex. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Trichothiodystrophy 1, photosensitive (TTD1) [MIM:601675]: A form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD1 patients manifest cutaneous photosensitivity. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Cerebro-oculo-facio-skeletal syndrome 2 (COFS2) [MIM:610756]: A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the helicase family. RAD3/XPD subfamily.

Protein post-translational modifications

ISGylated. .

Protein cellular localization

Nucleus . Cytoplasm, cytoskeleton, spindle .

Research area

<a href="">All research areas</a>><a href="">Transcription Regulators</a>><a href="">TFIIH</a><br><a href=""&gt; (View all antibody categories related to Transcription Regulators)</a>


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Product type

Primary antibody


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