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Rabbit Anti-ERLIN2 Antibody (CSB-PA007791ESR2HU)
Supplier: CUSABIO BIOTECH CO.
Erlin-2 Antibody,Endoplasmic reticulum lipid raft-associated protein 2 Antibody,Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 Antibody,SPFH domain-containing protein 2 Antibody,ERLIN2 Antibody,C8orf2 Antibody,SPFH2 Antibody,UNQ2441/PRO5003/PRO9924 AntibodyMore alternative names for the antibody
C8orf2 antibody|Chromosome 8 open reading frame 2 antibody|Endoplasmic reticulum lipid raft associated protein 2 antibody|Endoplasmic reticulum lipid raft-associated protein 2 antibody|ER lipid raft associated 2 antibody|ERLIN 2 antibody|Erlin-2 antibody|ERLIN2 antibody|ERLN2_HUMAN antibody|HGNC:1356 antibody|MGC87072 antibody|NET32 antibody|SPFH 2 antibody|SPFH domain containing protein 2 antibody|SPFH domain family member 2 antibody|SPFH domain-containing protein 2 antibody|SPFH2 antibody|SPG18 antibody|Stomatin prohibitin flotillin HflC/K domain containing protein 2 antibody|Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 antibody
Anti-SPFH2 antibody [EPR8088] (ab129207)
Anti-SPFH2 antibody [EPR8088] (ab129207)
Recommended applications: ELISA, WB, IHC
Recommended dilution: User optimized
Recommended protocols: check protocols
|Catalogue No.|| |
Recombinant human Erlin-2 protein (212-339AA)
ELISA, WB, IHC
|Recommended dilution|| |
|Molecular weight|| |
Antigen Affinity Purified
Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.
|Database links|| |
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11160" target="_blank">Entrez Gene:11160( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=244373" target="_blank">Entrez Gene:244373( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/omim/611605" target="_blank">Omim:611605( Human)</a>, <a href="http://www.uniprot.org/uniprot/O94905" target="_blank">SwissProt:O94905( Human)</a>, <a href="http://www.uniprot.org/uniprot/Q8BFZ9" target="_blank">SwissProt:Q8BFZ9( Mouse)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=705490" target="_blank">Unigene:705490( Human)</a>, <a href="http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=277699" target="_blank">Unigene:277699( Mouse)</a>
|Protein function|| |
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). .
|Protein tissue specificity|| |
|Involvement in disease|| |
Spastic paraplegia 18, autosomal recessive (SPG18) [MIM:611225]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG18 is a severe form with onset in early childhood. Most affected individuals have severe psychomotor retardation. Some may develop significant joint contractures. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the band 7/mec-2 family.
|Protein cellular localization|| |
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
|Research area|| |
<a href="https://antibodyplus.com/research-areas/">All research areas</a>><a href="https://antibodyplus.com/Signaling-Intermediates/">Signaling Intermediates</a>><a href="https://antibodyplus.com/product-tag/SPFH/">SPFH</a><br><a href="https://antibodyplus.com/product-tag/Signaling-Intermediates/"> (View all antibody categories related to Signaling Intermediates)</a>
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CUSABIO BIOTECH CO.
|Product type|| |
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