Anti-ERO1A Antibody

$99.00$319.00

Reactivity: Human
Applications: ELISA,WB,IHC
Conjugation: Various
Supplier: CUSABIO BIOTECH CO.

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Rabbit Anti-ERO1A Antibody (CSB-PA846631ESR2HU)

Supplier: CUSABIO BIOTECH CO.

Alternative names:

ERO1-like protein alpha Antibody,ERO1-L Antibody,ERO1-L-alpha Antibody,Endoplasmic oxidoreductin-1-like protein Antibody,Endoplasmic reticulum oxidoreductase alpha Antibody,ERO1A Antibody

More alternative names for the antibody
Endoplasmic oxidoreductin 1 like protein antibody|Endoplasmic oxidoreductin-1-like protein antibody|Endoplasmic reticulum oxidoreductin 1-like antibody|ERO1 alpha antibody|ERO1 L antibody|ERO1 Lalpha antibody|ERO1 like protein alpha antibody|ERO1-alpha antibody|ERO1-L antibody|ERO1-L-alpha antibody|ERO1-like (S. cerevisiae) antibody|ERO1-like alpha antibody|ERO1-like protein alpha antibody|ERO1-like, S. cerevisiae, homolog of, alpha antibody|ERO1A antibody|ERO1A_HUMAN antibody|ERO1L antibody|ERO1LA antibody|Oxidoreductin 1 Lalpha antibody|Oxidoreductin-1-L-alpha antibody|PRO865 antibody|UNQ434 antibody
Anti-ERO1L antibody [EPR12474] (ab177156)
Close sc-365526|sc-98354|sc-100805|

Recommended applications: ELISA, WB, IHC

Recommended dilution: User optimized

Recommended protocols: check protocols

Name

Anti-ERO1A Antibody

Catalogue No.

CSB-PA846631ESR2HU

Reactivity

Human

Immunogen

Recombinant human ERO1-like protein alpha protein (24-260AA)

Host

Rabbit

Applications

ELISA, WB, IHC

Recommended dilution

User optimized

Clonality

Polyclonal

Conjugation

unconjugated

Isotype

IgG

Molecular weight

54 kDa

Purification

Antigen Affinity Purified

Storage

Shipped at 4 Celcius Degree. Upon delivery aliquot and store at -20 Celcius Degree or -80 Celcius Degree. Avoid repeated freeze.

Database links

Entrez Gene:30001( Human), Entrez Gene:50527( Mouse), Omim:615435( Human), SwissProt:Q96HE7( Human), SwissProt:Q8R180( Mouse), Unigene:592304( Human), Unigene:387108( Mouse)

Protein function

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. .

Protein tissue specificity

Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. .

Protein sequence and domain

Belongs to the EROs family.

Protein post-translational modifications

N-glycosylated. .; The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397 (By similarity). The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131 (PubMed:23027870). .

Protein cellular localization

Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side . Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.

Research area

All research areas>Signaling Intermediates>Ero1
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus provides antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

CUSABIO BIOTECH CO.

Product type

Primary antibody

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